ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1991, Vol. 23 ›› Issue (1): 76-82.

• • 上一篇    下一篇

NMDA受体在海马习得性长时程突触增强形成中的作用

许世彤;易立;区英琦   

  1. 华南师范大学神经生理研究室,华南师范大学神经生理研究室,华南师范大学神经生理研究室 广州 ,广州 云南师范大学生物系 ,广州
  • 出版日期:1991-03-25 发布日期:1991-03-25
  • 通讯作者: 许世彤

THE ROLE OF N-METHYL-D-ASPARTATE RECEPIOR IN DEVELOPMENT OF LEARNING-DEPENDENT LONG-TERM SYNAPTIC POTENTIATION

Xu Shitong;Yi Li;Ou Yingqi(Neurophysiology Research Laboratory,South China Normal University. Guangzhou)   

  • Published:1991-03-25 Online:1991-03-25

摘要: 本文应用慢性埋植技术以电生理学结合行为学的方法,在大鼠条件性饮水反应的建立中,于每实验日训练开始前给海马CA_3区微量注射NMDA受体拮颃剂2-amino-5-phosphonovalerate(APV),观察它对海马CA_s区突触效应及与之相关的条件性行为反应的影响。发现注射APV后对CA_3区突触效应的习得性长时程增强的产生有显著的抑制性影响,相应地条件性饮水反应的建立也受到显著的抑制,提示NMDA受体参与习得性LTP的产主。

关键词: NULL

Abstract: The purpose of this study is to investigate the effect of microinjecti-on of 2-amino-5-phospho-novalerate (APV), N-methyl-D-aspartate(NMD-A) receptor antagonist, to the CA_3 region of the rat hippocampus on thesynaptic efficacy and relative conditioned behavior during establishmentof conditioned drinking response. The results showed that microinjection of APV caused significantlysuppression of the synaptic efficacy and the establishment of conditioneddrinking response. Moreover, the development level of long-term potenti-ation (LTP) is in advance of the development level of correlative condi-tioned behavior. These results indicated that the NMDA receptor is in-volved in the development of learning-dependent LTP.

Key words: NULL