ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1990, Vol. 22 ›› Issue (3): 84-89.

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Org-2766对小鼠学习记忆的影响及其与脑内蛋白质合成的关系

陈蓉;肖信生;王新光   

  1. 南京大学生物学系,南京大学生物学系 ,南京大学现代分析中心 南京神经精神病防治研究所
  • 发布日期:1990-09-25 出版日期:1990-09-25
  • 通讯作者: 陈蓉

RELATIONS BETWEEN THE FACILITATORY EFFECT OF ORG-2766 ON MEMORY CONSOLEDATION PROCESSES AND CEREBRAL PROTEIN SYNTHESIS IN MICE

Chen Rong;Wang Xinguang;Xiao Xinsheng Nanjing Neuropsychiatric Institute Nanjing University   

  • Online:1990-09-25 Published:1990-09-25

摘要： 以一次性被动回避反应和Y-迷宫分辨学习为学习记忆模型,研究了Org-2766对小鼠学习记忆的影响。结果表明:Org-2766能延缓小鼠被动回避反应的消退;促进分辨学习,并能改善由于注射茴香霉素而引起的遗忘。 以海马、丘脑突触体对[~3H]-亮氨酸的摄取影响,探讨了Org-2766促进记忆的作用与蛋白质合成的关系。结果表明:茴香霉素抑制海马、丘脑突触体摄取[~3H]-亮氨酸;Org-2766可减轻该抑制作用,使摄取量基本恢复正常。提示:Org-2766促进记忆的作用可能与脑内蛋白质有关。

关键词: NULL

Abstract: The effects of Org-2766 on one-trial passive avoidance response andY-maze discrimination learning in mice were studied. The results showedthat Org-2766 facilitated passive avoidance response,increasedthe retentionof Y-maze discrimination learning and prevented amnesia induced byanisomycin(ANI). The effects of Org-2766 on cerebral protein syn-thesis inhibited by ANI at the level of hippocampal and thalamic syna-ptosomes were also studied. The results showed that ANI reduced hipp-ocampal and thalamic synaptosomes uptaking[~3H]-Leucine. Org-2766could prevent the inhibitory effecb of ANI and keep the [~3H]-Leucineuptaking at normal level. These results suggest that facilitatory effect ofOrg-2766 on memory consolidation possibly is associated with the proteinsynthesis.

Key words: NULL