ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报

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童年期逆境与青少年应激心血管功能失调的关系：自主神经系统相关多基因的调节作用（压力、韧性与健康专刊投稿）

黄烨飞, 吕薇   

  1. 陕西师范大学心理学院陕西省行为与认知神经科学重点实验室，陕西省儿童青少年心理与行为健康重点研究中心, 陕西 710062 中国
  • 收稿日期:2025-07-22 修回日期:2025-12-23 接受日期:2025-12-26
  • 基金资助:
    国家自然科学基金(32171066)

Childhood Adversity and Adolescent Stress Cardiovascular Dysregulation: Moderating Role of Autonomic Nervous System Multilocus Genetic Variation

Huang Yefei, Lü Wei   

  1. Shaanxi Key Laboratory of Behavior and Cognitive Neuroscience, Shaanxi Key Research Center for Children Mental and Behavior Health, School of Psychology, Shaanxi Normal University 710062, China
  • Received:2025-07-22 Revised:2025-12-23 Accepted:2025-12-26
  • Supported by:
    National Natural Science Foundation of China(32171066)

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摘要： 童年期逆境与自主神经系统支配下的应激心血管反应功能失调有关，然而以往有关这种关联模式的研究结果并不一致。自主神经系统相关基因多态性参与调控应激心血管功能，同时作为风险环境的易感性特征也可能与童年期逆境交互影响应激心血管反应。但目前仍缺乏研究从环境和基因交互的视角探究两者对应激心血管反应性的影响。研究在两个独立样本(样本1包含256名青少年，Mage = 12.95 ± 0.79岁；样本2包含358名青少年，Mage = 12.98 ± 0.74岁)中探讨童年期逆境与青少年应激心血管反应性的关系，并采用多基因累加得分研究范式考察自主神经系统相关基因的调节作用。样本1和2分别采用两种经典的应激任务(即兴演讲任务和心算任务)验证结果。结果发现：在样本1和2中，童年期逆境与应激心血管反应性呈负相关；自主神经系统相关多基因累加得分在童年期逆境与应激心血管反应性关系中起着调节作用。具体而言，与多基因累加得分低的青少年相比，多基因累加得分高的青少年在高童年期逆境下表现出较小(钝化)的应激心血管反应，在低童年期逆境下表现出相对较大的应激心血管反应，支持差别易感模型。本研究从环境和基因交互的视角揭示了青少年应激心血管功能失调的形成机制，为改善青少年应激生理功能提供参考。

关键词: 童年期逆境, 应激心血管反应, 多基因累加得分

Abstract: Childhood adversity is one of the most important environmental risk factors that leads to stress cardiovascular dysregulation, which is innerved by the autonomic nervous system. Previous studies have either found childhood adversity is associated with lower or excessive cardiovascular reactivity to stress, yielding mixed findings. Not all the individuals exposed to childhood adversity exhibit similar pattern of cardiovascular reactivity to stress. Autonomic nervous system genetic polymorphisms are involved in modulating stress cardiovascular function, and is shown to as the markers of environmental sensitivity to interact with childhood adversity to impact developmental outcomes. However, few studies have examined the interaction effects of environmental factors and genetic polymorphisms on cardiovascular reactivity to stress among adolescents. Adopting the multilocus genetic profile score (MGPS) approach, the present study aimed to explore the associations between childhood adversity and adolescent cardiovascular reactivity to stress, and test the moderating role of the autonomic nervous system genetic polymorphisms. Two independent samples (sample 1 included 256 adolescents, Mage=12.95 ± 0.79 years old; Sample 2 included 358 adolescents, Mage=12.98 ± 0.74 years old) were recruited from two middle schools in northwest China. Cardiovascular reactivity was induced by a speech task and a mental arithmetic task in sample 1 and sample 2, respectively. The results showed that childhood adversity was negatively associated with cardiovascular reactivity to stress, and these associations were moderated by MGPS. Specifically, compared to adolescents with lower MGPS, those with higher MGPS exhibited lower (or blunt) cardiovascular reactivity to stress when exposed to more childhood adversity, and exhibited greater cardiovascular reactivity to stress when exposed to less childhood adversity. These findings suggest that childhood adversity and autonomic nervous system genetic polymorphisms interactively impact stress cardiovascular function among adolescents, and have implications for interventions targeted at improving stress cardiovascular function in adolescents with childhood adversity.

Key words: childhood adversity, stress cardiovascular reactivity, multilocus genetic profile score