The regularity and mechanism on immune response of psychosocial stress

doi:10.3724/SP.J.1042.2019.00821

Abstract

Abstract:

The psychosocial stress will make the immune system experience functional changes in aspects of immune defense, immune homeostasis and immune surveillance and also appear dynamic transition between abnormality and normality along with time and intensity of stress stimulation. Its mechanism is related to biological factors such as heredity, neuroendocrine, free radical metabolism and intestinal flora changes and the microglial cell maybe play an important mediating role in it. Lots of biological factors, demography factors such as age, gender and economic status as well as route jointly determine occurrence and development of immune reaction in psychosocial stress. As for its intervention, the physical exercise in kinesitherapy is a kind of method that is worthy of attention.

Key words: psychosocial stress, immune response, immune system

CLC Number:

B845

CUI Rongrong. The regularity and mechanism on immune response of psychosocial stress[J]. Advances in Psychological Science, 2019, 27(5): 821-833.

References 96

[1]	Armstrong, I. E., & Vanheest J.L, . ( 2002). The unknown mechanism of the overtraining syndrome clues from depression and psychoneuroimmunology. Sports Medicine, 32(3), 185-209.
[2]	Amati M., Tomasetti M., Ciuccarelli M., Mariotti L., Tarquini L. M., Bracci M., .. Santarelli L . ( 2010). Relationship of job satisfaction, psychological distress and stress-related biological parameters among healthy nurses: A longitudinal study. Journal of Occupational Health, 52(1), 31-38.
[3]	Archer T., Fredriksson A., Schütz E., & Kostrzewa R. M . ( 2011). Influence of physical exercise on neuroimmunological functioning and health: Aging and stress. Neurotoxicity Research, 20(1), 69-83. doi: 10.1007/s12640-010-9224-9 URL
[4]	Azzinnari D., Sigrist H., Staehli S., Palme R., Hildebrandt T., Leparc G., .. Pryce C. R . ( 2014). Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function. Neuropharmacology, 85, 328-341.
[5]	Baganz, N. L., Blakely, R. D . ( 2013). A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chemical Neuroscience, 4(1), 48-63.
[6]	Bartolomucci A., Sacerdote P., Panerai A. E., Pederzani T., Palanza P., & Parmigiani S . ( 2003). Chronic psychosocial stress-induced down-regulation of immunity depends upon individual factors. Journal of Neuroimmunology, 141(1-2), 58-64. doi: 10.1016/S0165-5728(03)00220-0 URL
[7]	Bellingrath S., Rohleder N., & Kudielka B. M . ( 2010). Healthy working school teachers with high effort-reward- imbalance and overcommitment show increased pro- inflammatory immune activity and a dampened innate immune defence. Brain Behavior & Immunity, 24(8), 1332-1339.
[8]	Bharwani A., Mian M. F., Foster J. A., Surette M. G., Bienenstock J., & Forsythe P . ( 2016). Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology, 63, 217-227.
[9]	Birkett M., Johnson L., & Gelety C . ( 2017). Investigation of sex differences in sIgA response to the trier social stress test. Stress Health, 33(2), 158-163.
[10]	Bienenstock J., Kunze W., & Forsythe P . ( 2015). Microbiota and the gut-brain axis. Nutrition Reviews, 73(1), 28-31.
[11]	Blandino P., Jr. Barnum C. J., Solomon L. G., Larish Y., Lankow B. S., & Deak T . ( 2009). Gene expression changes in the hypothalamus provide evidence for regionally- selective changes in IL-1 and microglial markers after acute stress. Brain Behavior & Immunity, 23(7), 958-968.
[12]	Bosch J. A., Fischer J. E., & Fischer J. C . ( 2009). Psychologically adverse work conditions are associated with CD8+T cell differentiation indicative of immunesenescence. Brain Behavior and Immunity, 23(4), 527-534.
[13]	Brachman R. A., Lehmann M. L., Maric D., & Herkenham M ., ( 2015). Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice. The Journal of Neuroscience, 35(4), 1530-1538. doi: 10.1523/JNEUROSCI.2278-14.2015 URL
[14]	Campisi J., Bravo Y., Cole J., & Gobeil K . ( 2012). Acute psychosocial stress differentially influences salivary endocrine and immune measures in undergraduate students. Physiology & Behavior, 107(3), 317-321.
[15]	Caserta M. T., O'Connor T. G., Wyman P. A., Wang H., Moynihan J., Cross W., .. Jin X . ( 2008). The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children. Brain Behavior & Immunity, 22(6), 933-940.
[16]	.. Penta A., Moreno B., Reix S., Fernandez-Diez B., Villanueva M., Errea O., .. Villoslada P . ( 2013). Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. PLoS One, 8(2), 1-12.
[17]	D'Ascola A., Bruschetta G., Zanghì G., Campo S., Medica P., Campana S., .. Ferlazzo A. M . ( 2018). Changes in plasma 5-HT levels and equine leukocyte SERT expression in response to treadmill exercise. Research in Veterinary Science, 118, 184-190.
[18]	Ehrnrooth E., Zacharia R., Svendsen G., Jørgensen M. M., Yishay M., Sørensen B. S … von der Maase H., ., ( 2002). Increased thymidylate synthase mRNA concentration in blood leukocytes following an experimental stressor. Psychother & Psychosom, 71(2), 97-103.
[19]	Elenkov, I. J . ( 2004). Glucocorticoids and the Th1/Th2 balance. Annals of the New York Academy of Sciences, 1024( 1), 138-146. doi: 10.1196/annals.1321.010 URL
[20]	Fang C. Y., Reibel D. K., Longacre M. L., Rosenzweig S., Campbell D. E., & Douglas S. D . ( 2010). Enhanced psychosocial well-being following participation in a mindfulness-based stress reduction program is associated with increased natural killer cell activity. Journal of Alternative & Complementary Medicine, 16(5), 531-538.
[21]	Filaire E., Larue J., Portier H., Abed A., Graziella P. D., Teixeira A., & Anne P . ( 2011). Lecturing to 200 students and its effects on cytokine concentration and salivary markers of adrenal activation. Stress Health, 27( 2), e25-35. doi: 10.1002/smi.v27.2 URL
[22]	Fuertig R., Azzinnari D., Bergamini G., Cathomas F., Sigrist H., Seifritz E., .. Pryce C. R . ( 2016). Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2, 3-dioxygenase. Brain Behavior and Immunity, 54, 59-72.
[23]	Foertsch S., Füchsl A. M., Faller S. D., Hölzer H., Langgartner D., Messmann J., Strauß G., & Rebe S. O . ( 2017). Splenic glucocorticoid resistance following psychosocial stress requires physical injury. Scientific Reports, 7(1), 1-12.
[24]	Gandhi R., Hayley S., Gibb J., Merali Z., & Anisman H . ( 2007). Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors. Brain Behavior & Immunity, 21(4), 477-489.
[25]	Gavrilovic L., Spasojevic N., & Dronjak S . ( 2010). Chronic individual housing-induced stress decreased expression of catecholamine biosynthetic enzyme genes and proteins in spleen of adult rats. Neuroimmunomodulation, 17(4), 265-269.
[26]	Geiger A. M., Pitts K. P., Feldkamp J., Kirschbaum C., & Wolf J. M . ( 2015). Cortisol-dependent stress effects on cell distribution in healthy individuals and individuals suffering from chronic adrenal insufficiency. Brain Behavior & Immunity, 50, 241-248.
[27]	Gibb J., Hayley S., Gandhi R., Poulter M. O., & Anisman H . ( 2008). Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: Circulating and brain cytokines, plasma corticosterone and behavioral changes in mice. Brain Behavior and Immunity, 22( 4), 573-589.
[28]	Gil S., Sampson T. R., Geschwind D. H., & Mazmanian S. K . ( 2016). The central nervous system and the gut microbiome. Cell, 167( 4), 915-932.
[29]	Götz, A. A., & Stefanski V. , ( 2007). Psychosocial maternal stress during pregnancy affects serum corticosterone, blood immune parameters and anxiety behaviour in adult male rat offspring. Physiology & Behavior, 90( 1), 108-115.
[30]	Götz A. A., Wittlinger S., & Stefanski V . ( 2007). Maternal social stress during pregnancy alters immune function and immune cell numbers in adult male Long-Evans rat offspring during stressful life-events. Journal of Neuroimmunology, 185( 1-2), 95-102.
[31]	Gonçalves L., Dafre A. L., Carobrez S. G., & Gasparotto O. C . ( 2008). A temporal analysis of the relationships between social stress, humoral immune response and glutathione-related antioxidant defenses. Behavioural Brain Research, 192( 2), 226-231.
[32]	Heidt T., Sager H. B., Courties G., Dutta P., Iwamoto Y., Zaltsman A., .. Nahrendorf M . ( 2014). Chronic variable stress activates hematopoietic stem cells. Nature Medicine, 20( 7), 754-758.
[33]	Hennessy M. B., Chun K., & Capitanio J. P . ( 2017). Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing. Social Neuroscience, 12( 1), 65-75. doi: 10.1080/17470919.2016.1145595 URL
[34]	Hintikka J., Lehto S. M., Niskanen L., Huotari A., Herzig K. H., Koivumaa-Honkanen H., .. Viinamäki H . ( 2009). Unemployment and ill health: A connection through inflammation? BMC Public Health, 12( 9), 1-6.
[35]	Hsu Y. C., Tsai S. F., Yu L., Chuang J. I., Wu F. S., Jen C. J., & Kuo Y. M . ( 2016). Long-term moderate exercise accelerates the recovery of stress-evoked cardiovascular responses. Stress, 19( 1), 125-132.
[36]	Ishihara Y., Takemoto T., Itoh K., Ishida A., & Yamazaki T . ( 2015). Dual role of superoxide dismutase 2 induced in activated microglia: Oxidative stress tolerance and convergence of inflammatory responses. The journal of Biological Chemistry, 290( 37), 22805-22817.
[37]	Johnson J. D., Zimomra Z. R., & Stewart L. T . ( 2013). Beta-adrenergic receptor activation primes microglia cytokine production. Journal of Neuroimmunology, 254( 1-2), 161-164. doi: 10.1016/j.jneuroim.2012.08.007 URL
[38]	Kami K., Taguchi S., Tajima F., & Senba E . ( 2016). Histone acetylation in microglia contributes to exercise- Induced hypoalgesia in neuropathic pain model mice. Journal of Pain, 17( 5), 588-599. doi: 10.1016/j.jpain.2016.01.471 URL
[39]	Kang D. H., Kim C. J., & Suh Y . ( 2004). Sex differences in immune responses and immune reactivity to stress in adolescents. Biological Research for Nursing, 5( 4), 243-254. doi: 10.1177/1099800403262749 URL
[40]	Kondo N., Suda Y., Nakao A., Oh-Oka K., Suzuki K., Ishimaru K., .. Yamagata Z . ( 2011). Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk. Pediatric Allergy & Immunology, 22( 8), 853-861.
[41]	Kritas S. K., Saggini A., Cerulli G., Caraffa A., Antinolfi P., Pantalone A., .. Conti P . ( 2014). Corticotropin- releasing hormone, microglia and mental disorders. International Journal of Immunopathology and Pharmacology, 27( 2), 163-167. doi: 10.1177/039463201402700203 URL
[42]	Lamb A. L., Hess D. E., Edenborn S., Ubinger E., Carrillo A. E., & Appasamy P. M . ( 2017). Elevated salivary IgA, decreased anxiety, and an altered oral microbiota are associated with active participation on an undergraduate athletic team. Physiology & Behavior, 169, 169-177.
[43]	Laurent H. K., Stroud L. R., Brush B., D'Angelo C., & Granger D. A . ( 2015). Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior. Psychoneuroendocrinology, 59, 81-90.
[44]	Li Z., Ma L., Kulesskaya N., Võikar V., & Tian L . ( 2014). Microglia are polarized to M1 type in high-anxiety inbred mice in response to lipopolysaccharide challenge. Brain Behavior and Immunity, 38, 237-248.
[45]	Lin S. L., Huang C. Y., Shiu S. P., & Yeh S. H . ( 2015). Effects of yoga on stress, stress adaption, and heart rate variability among mental health professionals—A randomized controlled trial. Worldviews on Evidence- Based Nursing, 12( 4), 236-245. doi: 10.1111/wvn.2015.12.issue-4 URL
[46]	Littlefield A. M., Setti S. E., Priester C., & Kohman R. A . ( 2015). Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice. Journal of Neuroinflammation, 30( 12), 1-12.
[47]	Lee M., . ( 2013). Neurotransmitters and microglial-mediated neuroinflammation. Current Protein & Peptide Science, 14( 1), 21-32.
[48]	Lehmann M. L., Cooper H. A., Maric D., & Herkenham M . ( 2016). Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages. Journal of Neuroinflammation, 13( 1), 1-19. doi: 10.1186/s12974-015-0467-5 URL
[49]	Lu Y., Dong Y., Tucker D., Wang R., Ahmed M. E., Brann D., & Zhang Q . ( 2017). Treadmill exercise exerts neuroprotection and regulates microglial polarization and oxidative stress in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Journal of Alzheimer's disease, 56( 4), 1469-1484. doi: 10.3233/JAD-160869 URL
[50]	Lucas T., Wegner R., Pierce J., Lumley M. A., Laurent H. K., & Granger D. A . ( 2017). Perceived discrimination, racial identity, and multisystem stress response to social evaluative threat among African American men and women. Psychosomatic Medicine, 79( 3), 293-305.
[51]	Mathews H. L., Konley T., Kosik K. L., Krukowski K., Eddy J., Albuquerque K., & Janusek L. W . ( 2011). Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress. Brain Behavior & Immunity, 25( 5), 830-839.
[52]	Masson G. S., Nair A. R., Soares, Michelinil L. C., & Francis J . ( 2015). Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR. American Journal of Physiology Heart & Circulatory Physiology, 309( 7), H1115-H1122.
[53]	McKim D. B., Niraula A., Tarr A. J., Wohleb E. S., Sheridan J. F., & Godbout J. P . ( 2016). Neuroinflammatory dynamics underlie memory impairments after repeated social defeat. Journal of Neuroscience, 36( 9), 2590-2604.
[54]	Meier, N. F., & Welch A.S, . ( 2016). Walking versus biofeedback: a comparison of acute interventions for stressed students. Anxiety, Stress, & Coping, 29( 5), 463-478.
[55]	Menard C., Pfau M. L., Hodes G. E., Kana V., Wang V. X., Bouchard S., .. Russo. S. J . ( 2017). Social stress induces neurovascular pathology promoting depression. Nature Neuroscience, 20( 12), 1752-1760.
[56]	Nishii A., Amemiya S., Kubota N., Nishijima T., & Kita I . ( 2017). Adaptive Changes in the sensitivity of the dorsal raphe and hypothalamic paraventricular nuclei to acute exercise, and hippocampal neurogenesis may contribute to the antidepressant effect of regular treadmill running in rats. Frontiers in Behavioral Neuroscience, 11, 1-13.
[57]	Noto Y., Kudo M., & Hirota K . ( 2010). Back massage therapy promotes psychological relaxation and an increase in salivary chromogranin A release . Journal of Anesthesia, 24( 6), 955-958. doi: 10.1007/s00540-010-1001-7 URL
[58]	Nyuyki K. D., Beiderbeck D. I., Lukas M., Neumann I. D., & Reber S. O . ( 2012). Chronic subordinate colony housing (CSC) as a model of chronic psychosocial stress in male rats. PLoS One, 7( 12), 1-11.
[59]	Osler M., Bendix L., Rask L., & Rod N. H . ( 2016). Stressful life events and leucocyte telomere length: Do lifestyle factors, somatic and mental health, or low grade inflammation mediate this relationship? Results from a cohort of Danish men born in 1953. Brain Behavior and Immunity, 58, 248-253.
[60]	Panter-Brick C., Eggerman M., Mojadidi A., & McDade T. W . ( 2008). Social stressors, mental health, and physiological stress in an urban elite of young Afghans in Kabul. American Journal of Human Biology, 20( 6), 627-641.
[61]	Petra A. I., Panagiotidou S., Hatziagelaki E., Stewart J. M., Conti P., & Theoharides T. C . ( 2015). Gut-microbiota- brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation. Clinical Therapeutics, 37( 5), 984-995. doi: 10.1016/j.clinthera.2015.04.002 URL
[62]	Peters E. M. J., Müller Y., Snaga W., Fliege H., Reißhauer A., Schmidt-Rose T., .. Kruse J . ( 2017). Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress. PLoS One, 12( 4), 1-21.
[63]	Pietrelli A., Di-Nardo M., Masucci A., Brusco A., Basso N., & Matkovic L . ( 2018). Lifelong aerobic exercise reduces the stress response in rats. Neuroscience, 376, 94-107.
[64]	Ramirez K., Niraula A., & Sheridan J. F . ( 2016). GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations. Brain Behavior and Immunity, 51, 154-68.
[65]	Ramirez K., & Sheridan J.F, . ( 2016). Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive-like behaviors. Brain Behavior and Immunity, 57, 293-303.
[66]	Reader B. F., Jarrett B. L., McKim D. B., Wohleb E. S., Godbout J. P., & Sheridan J. F . ( 2015). Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety. Neuroscience, 289, 429-442.
[67]	Reber S. O., Peters S., Slattery D. A., Hofmann C., Schölmerich J., Neumann I. D., & Obermeier F . ( 2011). Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stress-induced colitis. Brain Behavior and Immunity, 25( 6), 1153-1161.
[68]	Ritz T., Trueba A. F., Vogel P. D., Auchus R. J., & Rosenfield D . ( 2017). Exhaled nitric oxide and vascular endothelial growth factor as predictors of cold symptoms after stress. Biological Psychology, 132, 116-124.
[69]	Ronaldson A., Gazali A. M., Zalli A., Kaiser F., Thompson S. J., Henderson B., … Carvalho L . ( 2016). Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women. Psychopharmacology, 233( 9), 1661-1668.
[70]	Romero-Martínez Á. & Moya-Albiol L. , ( 2017). Stress- induced endocrine and immune dysfunctions in caregivers of people with eating disorders. International Journal of Environmental Research & Public Health, 14( 12), 1-10.
[71]	Sawicki C. M., Kim J. K., Weber M. D., Jarrett B. L., Godbout J. P., Sheridan J. F., & Humeidan M . ( 2017). Ropivacaine and Bupivacaine prevent increased pain sensitivity without altering neuroimmune activation following repeated social defeat stress. Brain Behavior & Immunity, 69, 113-123.
[72]	Schmidt D., Reber S. O., Botteron C., Barth T., Peterlik D., Uschold N., .. Lechner A . ( 2010). Chronic psychosocial stress promotes systemic immune activation and the development of inflammatory Th cell responses. Brain Behavior & Immunity, 24( 7), 1097-1104.
[73]	Schmidt D., Peterlik D., Reber S. O., Lechner A., & Männel D. N . ( 2016). Induction of suppressor cells and increased tumor growth following chronic psychosocial stress in male mice. PLoS One, 11( 7), 1-18.
[74]	Schmidt T., Jonat W., Wesch D., Oberg H. H., Adam- Klages S., Keller L., & Mundhenke C . ( 2018). Influence of physical activity on the immune system in breast cancer patients during chemotherapy. Journal of Cancer Research & Clinical Oncology, 144( 3), 579-586.
[75]	Schneble N., Schmidt C., Bauer R., Müller J. P., Monajembashi S., & Wetzker R . ( 2017). Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility. Molecular and Cellular Neuroscience, 78, 1-8.
[76]	Scotti M. A. L., Carlton E. D., Demas G. E., & Grippo A. J . ( 2015). Social isolation disrupts innate immune responses in both male and female prairie voles and enhances agonistic behavior in female prairie voles (Microtus ochrogaster). Hormones & Behavior, 70, 7-13.
[77]	Sharma H., Datta P., Singh A., Sen S., Bhardwaj N. K., Kochupillai V., & Singh N . ( 2008). Gene expression profiling in practitioners of Sudarshan Kriya. Journal of Psychosomatic Research, 64( 2), 213-218.
[78]	Sorensen M. V., Snodgrass J. J., Leonard W. R., McDade T. W., Tarskaya L. A., Ivanov K. I., .. Alekseev V. P . ( 2010). Lifestyle incongruity, stress and immune function in indigenous Siberians: The health impacts of rapid social and economic change. American Journal of Physical Anthropology, 138( 1), 62-69.
[79]	Stefanski V. & Grüner S. , ( 2006). Gender difference in basal and stress levels of peripheral blood leukocytes in laboratory rats. Brain Behavior & Immunity, 20( 4), 369-377.
[80]	Strahler J., Rohleder N., & Wolf J. M . ( 2015). Acute psychosocial stress induces differential short-term changes in catecholamine sensitivity of stimulated inflammatory cytokine production. Brain Behavior and Immunity, 43, 139-148.
[81]	Shen C., Ma Y., Zeng Z., Yin Q., Hong Y., Hou X., & Liu X . ( 2017). RAGE-specific inhibitor FPS-ZM1 attenuates AGEs-induced neuroinflammation and oxidative stress in rat primary microglia. Neurochemical Research, 42( 10), 2902-2911. doi: 10.1007/s11064-017-2321-x URL
[82]	Tanaka K. F., Kashima H., Suzuki H., Ono K., & Sawada M . ( 2002). Existence of functional β1- and β2-adrenergic receptors on microglia. Journal of Neuroscience Research, 70( 2), 232-237. doi: 10.1002/(ISSN)1097-4547 URL
[83]	Tometten M., Blois S., Kuhlmei A., Stretz A., Klapp B. F., & Arck P. C . ( 2006). Nerve growth factor translates stress response and subsequent murine abortion via adhesion molecule-dependent pathways. Biology of Reproduction, 74( 4), 674-683. doi: 10.1095/biolreprod.105.044651 URL
[84]	Tiina F., Julia P., Elina H., Tero M. H., Lindholm H. R., & Urho M. K . ( 2016). Physical activity, body mass index and heart rate variability-based stress and recovery in 16275 Finnish employees: A cross-sectional study. BMC Public Health, 16, 701-713.
[85]	Visnovcova Z., Mokra D., Mikolka P., Mestanik M., Jurko A., Javorka M., … Tonhajzerova I . ( 2015). Alterations in vagal-immune pathway in long-lasting mental stress. The Advances in Experimental Medicine and Biology, 832, 45-50.
[86]	Vitlic A., Lord J. M., Taylor A. E., Arlt W., Bartlett D. B., Rossi A., .. Phillips A. C . ( 2016). Neutrophil function in young and old caregivers. British Journal Health Psychology, 21( 1), 173-189.
[87]	von-Haaren B., Ottenbacher J., Muenz J., Neumann R., Boes K., & Ebner-Priemer U . ( 2016). Does a 20 week aerobic exercise training programme increase our capabilities to buffer real-life stressors? A randomized, controlled trial using ambulatory assessment . European Journal of Applied Physiology, 116, 383-394. doi: 10.1007/s00421-015-3284-8 URL
[88]	von Leden R. E., Khayrullina G., Moritz K. E., & Byrnes K. R . ( 2017). Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury. Journal of Neuroinflammation, 14( 1), 161.
[89]	von Rueden C. R., Trumble B. C., Emery Hompson M., Stieglitz J., Hooper P. L., Blackwell A. D., … Gurven M . ( 2014). Political influence associates with cortisol and health among egalitarian forager-farmers. Evolution, Medicine, and Public Health, 1, 122-133.
[90]	Wohleb E. S., Hanke M. L., Corona A. W., Powell N. D., Stiner L.M., .. Sheridan J.F . ( 2011). β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. Journal of Neuroscience, 31( 17), 6277-6288.
[91]	Wong S. Y. S., Wong C. K., Chan F. W. K., Chan P. K. S., Ngai K., Mercer S., & Woo J . ( 2013). Chronic psychosocial stress: Does it modulate immunity to the influenza vaccine in Hong Kong Chinese elderly caregivers? Age, 35( 4), 1479-1493.
[92]	Yamakawa K., Matsunaga M., Isowa T., & Ohira H . ( 2015). Serotonin transporter gene polymorphism modulates inflammatory cytokine responses during acute stress. Scientific Reports, 5, 138-52.
[93]	Yoon H. S., Lee K. M., & Kang D . ( 2014). Intercorrelation between immunological biomarkers and job stress indicators among female nurses: A 9-month longitudinal study. Frontiers in Public Health, 2( 4), 2042-2054.
[94]	Yuan T. F., Hou G., Zhao Y., & Arias-Carrión O . ( 2015). Commentary: The effects of psychological stress on microglial cells in the brain. CNS & Neurological Disorders- Drug Targets, 14( 3), 304-308.
[95]	Zhu X., Han Y., Du J., Liu R., Jin K., & Yi W . ( 2017). Microbiota-gut-brain axis and the central nervous system. Oncotarget, 8( 32), 53829-53838.
[96]	Zschucke E., Renneberg B., Dimeo F., Wüstenberg T., & Ströhle A . ( 2015). The stress-buffering effect of acute exercise: Evidence for HPA axis negative feedback. Psychoneuroendocrinology, 51, 414-425.