Abstract:

Drug addiction is a disease with central nervous system dysfunction. Muscarinic receptor belong to cholinergic system, has five subtypes, M1-M5 receptors. Behavioral research show that interference with M receptor could affect drug addiction behavior. Both opioids and psychoactive drugs could active central DA system. And M receptor regulating dopamine system in various brain areas, implicate there is a potential way that M receptor affect addiction behavior through interaction with DA system. Activing M2 and M4 receptor could inhibit DA system activating, and active M5 receptor could facilitate DA system activating, in corresponding to the effect of intervened with M2、M4、M5 receptor in drug addiction behavioral research. These evidences prove that M receptor regulating DA system in drug addiction behavior, and M receptor could be new neural target for treatment of drug addiction.

Key words: drug addiction, muscarinic receptor, dopamine, cholinergic system