Abstract: Apraxic agraphia refers to the phenomenon that people can’t write or can’t write correctly though they know how to write. The neural network involving in apraxic agraphia includes the cortico-cortical connection and cortico-subcortical junction. Three subtypes involved in the cortico-cortical connection include the frontal-parietal junction, the parieto-occipital connection and the network which is associated with the frontal lobe, parietal lobe, occipital lobe and temporal lobe. These subtypes are in charge of the spatial manipulations of represented images, recalling and retrievaling the forms of characters. The other neural network is the cortico-subcortical junction, which consisted of the cerebellar-cortical connection, thalamo-cortical junction, and the network including the corpus striatum, internal capsule and cerebral cortex. They are related to the graphic output programming, the formation of grapheme, and the praxis command. Future researches need focus on psychological and mental mechanism of apraxic agraphia and rehabilitation work of it.

Key words: apraxia agraphia, neuroimaging technologies, neural network, neural mechanism