Abstract: In Computerized Cognitive Behavioral Therapy (CCBT), those basic principles and methods commonly used in traditional Cognitive Behavioral Therapy are embodied through computer interface, clear instructions to operation, and highly structured multi-media (e.g. webpage, cartoon, animation, video, audio etc.). The application of CCBT to depression emerged recently, and some CCBT programs (e.g. Beating The Blues、MoodGYM、E-Couch, and Good Days Ahead) have been popularly applied to the treatment of depression. Eligibility analysis found that CCBT was able to be accepted by patients, high-cost and easy for usage. The effectiveness of CCBT has been evidenced by existing studies, yet relies on a number of factors. The limitations of existing studies involve insufficient attention to the mechanism of effectiveness, significant difference in therapeutic effect among different studies, simplistic risk evaluation, and bias in subject selection. The issues should be emphasized in future studies are (1) mediation effect and mechanism; (2) human-centered individualized services, (3) risk evaluation and privacy protection; (4) focusing on social vulnerable groups. At last, the necessity and eligibility of the development of CCBT in China was discussed.

Key words: depression, Computerized Cognitive-Behavioral Therapy, mechanism, mediating effect, evidence- based practice