Abstract:

In the past decades, researchers have investigated the neural basis of developmental dyslexia and revealed the specific regional abnormality in dyslexics with a view of brain functional localization. However, given the complexity of reading process and its engagement of multiple regions, more and more researchers have studied this issue from an inter-regional brain connectivity perspective in recent years. These studies revealed that dyslexics exhibited disruption in both white matter structural connectivity and functional connectivity. These findings suggest a tight link between reading impairment and abnormalities in inter- regional brain connectivity. Future studies should explore the relationship between the connectivity disruption and specific regional abnormality in dyslexia and combine gene, brain, behavior, and environmental factors to investigate the pathogenetic mechanism of dyslexia.

Key words: developmental dyslexia, neural basis, structural connectivity, task-based functional connectivity, resting-state functional connectivity