反馈相关负波：一种抑郁症的生物标记物

doi:10.3724/SP.J.1042.2021.00404

摘要/Abstract

摘要：

反馈相关负波(feedback-related negativity, FRN)是一种反映个体奖赏敏感性的脑电成分; 而抑郁症患者的特征之一是奖赏敏感性的减弱。大量横向研究发现了重度抑郁症患者(major depressive disorder, MDD)及有患抑郁症风险群体的FRN异常; 另外, 纵向研究发现FRN的异常能够预测青春期抑郁发作及抑郁症状发展, 压力、睡眠等因素在其中起调节作用。这提示FRN可能在对抑郁症的诊断及分型、抑郁高危群体的筛查及干预等方面具有潜在价值。目前关于FRN的心理功能依然存在一些争议, 在未来的研究中应该进一步明确FRN的功能和测量方法, 并探明抑郁症的异质性和共病对FRN的作用, 也应关注老年人群体中FRN与抑郁症的关系。

Abstract:

Feedback-related negativity (FRN) is an Electroencephalogram (EEG) component that reflects an individual’s reward sensitivity. Depression is usually characterized by decreased reward sensitivity. Several cross-sectional studies have found abnormal FRN in patients with major depressive disorder (MDD) and in those at risk of depression. Moreover, longitudinal studies have found that abnormal FRN can predict the onset of adolescent depression and the development of depressive symptoms; in this process, stress and sleep are two essential moderators. This suggests that FRN may have potential value in the diagnosis and classification of depression and the screening and intervention of high-risk groups of depression. Presently, some controversies regarding the psychological function of FRN still exist. In future research, the function and measurement of FRN should be further clarified, and the effects of heterogeneity and comorbidities of depression on FRN should be further examined. We should also focus on the relationship between FRN and depression in the elderly.

Key words: feedback-related negativity, reward positivity, depression, reward system, event-related potentials

中图分类号:

B845

秦浩方, 黄蓉, 贾世伟. (2021). 反馈相关负波：一种抑郁症的生物标记物. 心理科学进展 , 29(3), 404-413.

QIN Haofang, HUANG Rong, JIA Shiwei. (2021). Feedback-related negativity: A biomarker for depression. Advances in Psychological Science, 29(3), 404-413.

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