ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2010, Vol. 18 ›› Issue (8): 1256-1262.

• • 上一篇    下一篇

COMT基因多态性与攻击行为的关系

王美萍;张文新   

  1. 山东师范大学心理学院, 济南 250014
  • 收稿日期:2010-03-16 修回日期:1900-01-01 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 张文新

Association Between Aggressive Behavior and A Functional Polymorphism in the COMT Gene

WANG Mei-Ping;ZHANG Wen-Xin   

  1. School of Psychology, Shandong Normal University, Jinan, 250014, China
  • Received:2010-03-16 Revised:1900-01-01 Online:2010-08-15 Published:2010-08-15
  • Contact: ZHANG Wen-Xin

PDF (PC)

2101

被引次数

36

摘要： 攻击行为的发生具有重要的遗传学基础。近年来, 随着分子遗传学的发展, 对攻击行为发生机制的研究已经深入到分子水平, COMT基因成为攻击行为遗传学研究的候选基因之一, 然而以人类为被试的研究结论尚存在分歧, 甚至相互矛盾。通过回顾、梳理既有关于COMT基因多态性与个体攻击行为关系的研究, 剖析了研究结论尚存在分歧和矛盾的原因, 并在此基础上从SNP标记、被试群体、研究设计、神经生物机制等几个方面展望了未来研究的方向。

关键词: COMT基因多态性, rs4680, rs6267, 攻击行为

Abstract: The development of aggressive behavior has important genetic underpinning. With the advancement of molecular genetics, research on the mechanism underlying aggressive behavior has extended to the molecular level in recent years. A number of studies have identified the COMT (Catechol-O-methyltransferase) gene as one of the candidate genes related to aggressive behavior. However, research findings on human subjects have not been always consistent and even contradictory in some cases. This paper reviewed the recent literature about the effect of the COMT gene on aggressive behavior and analyzed causes of the inconsistencies of research findings. Finally, directions of future research were discussed.

Key words: COMT polymorphism, rs4680, rs6267, aggressive behavior