高风险婴儿前瞻性纵向研究与孤独症谱系障碍早期识别

doi:10.3724/SP.J.1042.2020.00443

摘要/Abstract

摘要：

孤独症谱系障碍(Autism Spectrum Disorder, ASD)早期识别有助于早期诊断和早期干预的实施, 对于改善ASD儿童发育结果至关重要。高风险前瞻性纵向研究以高风险婴儿(ASD儿童的年幼同胞, 入组年龄小于12个月)作为主要研究对象, 通过对ASD高风险婴儿(24至36个月之间诊断为ASD的高风险婴儿)的早期发育轨迹的描绘和核心症状早期表现的识别, 为ASD早期识别提供了重要依据。未来可以增加被试数量、延长观察时间并密集观察时间点、关注伴发障碍、综合考虑遗传、环境和文化因素影响, 并结合早期干预研究进行深入探索。未来在中国开展相关研究具有重要的科学价值和临床意义。

关键词: 孤独症谱系障碍, 早期识别, 前瞻性纵向研究, 高风险婴儿, 发育轨迹

Abstract:

The early identification of autism spectrum disorder (ASD) facilitates early diagnosis and appropriate intervention; that is crucial for ensuring positive developmental outcomes. Evidence from prospective longitudinal studies in high-risk infants (younger siblings of ASD children enrolled before 12 months old) has exhibited the influence of the early identification of ASD by demonstrating developmental trajectories and identifying early manifestations of core symptoms in high-risk ASD infants (who are diagnosed with ASD between 24 and 36 months old). It has been thereby suggested that more subjects, prolonged observation durations, and intensive time points should be adopted in future studies. Additionally, more attention should be paid to ASD-related disorders and early intervention for high-risk infants. In addition, the impact of genetic, environmental, cultural and social factors must also be considered. It is believed that prospective longitudinal studies in high-risk infants in China will assuredly make a distinct difference, both scientifically and clinically.

Key words: autism spectrum disorder, early identification, prospective longitudinal studies, high-risk infants, developmental trajectory

毕小彬, 范晓壮, 米文丽, 贺荟中. (2020). 高风险婴儿前瞻性纵向研究与孤独症谱系障碍早期识别. 心理科学进展 , 28(3), 443-455.

BI Xiaobin, FAN Xiaozhuang, MI Wenli, HE Huizhong. (2020). Early identification of autism spectrum disorder in prospective longitudinal studies of high-risk infants. Advances in Psychological Science, 28(3), 443-455.

图/表 1

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