ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2013, Vol. 21 ›› Issue (6): 999-1006.doi: 10.3724/SP.J.1042.2013.00999

• 生理心理学专栏 • 上一篇    下一篇

胚胎期可卡因、吗啡暴露影响子代成瘾相关行为的神经发育机制

王园园;王冬梅;隋南   

  1. (1中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京 100101) (2中国科学院大学, 北京 100049)
  • 收稿日期:2013-02-21 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 隋南
  • 基金资助:

    中国科学院心理健康重点实验室自主研究课题(cx113000c136), 国家自然科学基金(31170988)和国家重点基础研究发展计划(973) (2009CB522002)资助项目。

Neurodevelopmental Mechanisms of Prenatal Cocaine or Morphine Exposure on Addiction-related Behaviors in Offsprings

WANG Yuanyuan;WANG Dongmei;SUI Nan   

  1. (1 Institute of Psychology. Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2013-02-21 Online:2013-06-15 Published:2013-06-15
  • Contact: SUI Nan

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摘要： 孕期使用毒品可影响胎儿大脑的正常发育, 导致脑内神经递质系统异常以及行为的改变。近年来不断有研究证据提示, 胚胎期接触可卡因、吗啡等成瘾药物, 可以影响神经细胞的增殖、迁移或凋亡等发育过程, 使中脑皮层边缘系统中多巴胺、GABA、谷氨酸等神经元形态、受体功能以及突触可塑性发生改变, 从而导致子代的学习记忆和成瘾易感性等行为异常。本文将从行为、神经发育、递质系统以及脑功能等层面归纳胚胎期用药对成瘾相关行为影响机制的重要研究进展, 并试图提出可能的研究展望。

关键词: 胚胎期, 可卡因, 吗啡, 脑发育, 成瘾行为

Abstract: Prenatal exposure to addictive drugs can influence the development of fetal brain, leading to abnormality of the main neurotransmitter system and behavioral malfunction. Recent studies showed that prenatal exposure to cocaine or morphine affects the proliferation, migration and apoptosis of neural progenitor, resulting in changes of neuronal morphology, receptor function and synaptic plasticity. Such changes are widely found in dopamine, GABA and glutamate system in mesocorticolimbic system, which leads to behavioral deficits in learning and memory and altered susceptibility to addictive drugs. Here we summarize related studies on behaviors, neural development, neurotransmitter system and brain function and try to put forward further research prospects.

Key words: embryonic period, cocaine, morphine, brain development, addiction behavior