ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2013, Vol. 21 ›› Issue (6): 1007-1013.doi: 10.3724/SP.J.1042.2013.01007

• 生理心理学专栏 • 上一篇    下一篇

增塑剂DEHP的神经和行为发育毒性

杨艳玲;徐晓虹   

  1. (浙江师范大学化学与生命科学学院, 金华 321004)
  • 收稿日期:2013-01-14 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 徐晓虹
  • 基金资助:

    国家自然科学基金项目(81172627), 浙江省自然科学基金重点项目(Z2090955)。

Neural and Behavioral Developmental Toxicity of the Plasticizer DEHP

YANG Yanling;XU Xiaohong   

  1. (College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China)
  • Received:2013-01-14 Online:2013-06-15 Published:2013-06-15
  • Contact: XU Xiaohong

PDF (PC)

1881

被引次数

7

摘要： 增塑剂邻苯二甲酸二乙基己酯(Di-(2-ethylhexyl) phthalate, DEHP)是一种具有拟雌激素和抗雄激素活性的环境内分泌干扰物, 人类和野生动物可通过不同途径终生暴露于DEHP。母体摄入的DEHP可通过胎盘和乳汁转入子代体内并进入脑组织。围生期DEHP暴露性别特异性地改变子代大鼠下丘脑视前区芳香酶活性而影响雌激素合成, 并通过改变雌激素受体活性干扰雌激素对脑发育的调节作用。DEHP及其代谢产物可以影响神经细胞的增殖分化和突触形成, 干扰性激素调控发育过程中的下丘脑氨基酸递质系统对促性腺激素释放激素分泌的刺激作用, 影响中脑多巴胺递质系统发育而诱导自发性多动症。DEHP对脑发育的作用最终影响动物的早期行为、学习记忆和情感等行为发育。

关键词: 邻苯二甲酸二乙基己酯, 神经发育毒性, 环境内分泌干扰物

Abstract: Di-(2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor that possesses weak estrogenic and anti-androgenic activity. Humans and wildlife exposed to DEHP lifetime through different channels. Maternal DEHP can be transferred either to the fetus across the placenta during pregnancy, or to the nursing infant through breast milk during lactation. Perinatal DEHP exposure can interfere with the effect of estrogen on brain development through sex-specifically changing the activities of aromatase enzyme and estrogen receptor in hypothalamic preoptic area of rat offspring. DEHP and its metabolites affect the proliferation and differentiation of neurons, synapse formation, and the regulatory effects of amino acid neurotransmitters system on gonadotropin releasing hormone (GnRH) neurons which are modulated by sexual hormones. DEHP affects the development of dopamine neurotransmitter system of the midbrain and induces motor hyperactivity. These effects of DEHP ultimately lead to abnormal development of behaviors such as early behavior, learning and memory, and emotional behavior of animal.

Key words: di-(2-ethylhexyl) phthalate, neural developmental toxicity, environmental endocrine disruptor