心理科学进展 ›› 2025, Vol. 33 ›› Issue (1): 42-61.doi: 10.3724/SP.J.1042.2025.0042
赵子卿1, 余锦婷2, 陈嘉彦3,4, 王芸茹3,4, 黄佳3,4(), 陈楚侨3,4(
)
收稿日期:
2024-04-28
出版日期:
2025-01-15
发布日期:
2024-10-28
通讯作者:
陈楚侨, E-mail: rckchan@psych.ac.cn;基金资助:
ZHAO Ziqing1, YU Jinting2, CHEN Jiayan3,4, WANG Yunru3,4, HUANG Jia3,4(), Raymond C.K. CHAN3,4(
)
Received:
2024-04-28
Online:
2025-01-15
Published:
2024-10-28
摘要:
精神病临床高危(clinical high-risk for psychosis, CHR-P)人群的症状和功能发展存在异质性, 澄清这个群体症状和功能的改变及联系, 有利于精神病早期预防。元分析纳入54篇文献, 探究CHR-P人群各维度临床症状和功能的纵向改变、基线症状对随访功能的预测作用、调节效应。 结果发现,CHR-P人群轻微阳性症状、阴性症状、瓦解症状、情感症状、一般精神病理症状、整体功能和角色功能随时间显著改善, 社会功能没有显著改善; 基线阴性症状显著负向预测随访的整体功能、社会功能、角色功能, 基线的瓦解症状、情感症状、一般精神病理症状与随访的整体功能显著负相关; 受教育程度显著调节轻微阳性症状和阴性症状的纵向变化, 年龄、轻微阳性症状亚组比例和短暂间歇性精神病性症状亚组比例显著调节情感症状的纵向变化。这揭示阴性症状改善少和社会功能损害是CHR-P人群的核心特征, 提示未来可针对阴性症状研发干预措施, 进而改善社会功能。
中图分类号:
赵子卿, 余锦婷, 陈嘉彦, 王芸茹, 黄佳, 陈楚侨. (2025). 精神病临床高危人群的症状和功能改变:一项系统综述和三水平元分析. 心理科学进展 , 33(1), 42-61.
ZHAO Ziqing, YU Jinting, CHEN Jiayan, WANG Yunru, HUANG Jia, Raymond C.K. CHAN. (2025). Changes in symptoms and functional outcomes in individuals at clinical high-risk for psychosis: A systematic review and three-level meta-analysis. Advances in Psychological Science, 33(1), 42-61.
第一作者 及年份 | 效应量数 | 取样 地区 | 随访时间(年) | 样本量 | 年龄(岁) | 性别(男性比例%) | 教育程度(年) | CHR-P亚组 | 精神病转化率(%) | 诊断工具 | 症状评 估工具 | 功能评 估工具 | 文献质量 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
APS比例(%) | BLIPS比例(%) | GRD比例(%) | COGDIS比例(%) | |||||||||||||
Pelizza et al., | 4 | 欧洲 | <1 | 87 | 18.21 | 52 | 11.06 | 78.70 | 16.90 | 4.50 | 8.10 | CAARMS | PANSS | GAF/ HoNOS | ||
Zhang et al., | 2 | 亚洲 | 2~3 | 59 | 19.80 | 48 | 10.60 | 25.40 | SIPS | GAF | ||||||
Værnes et al., | 1 | 欧洲 | <1 | 32 | 19.90 | 66 | 11.70 | 75.00 | 3.10 | 37.40 | 12.50 | SIPS | SIPS | GAF | ||
Usui et al., | 1 | 亚洲 | 1~2 | 22 | 21.10 | 46 | 13.00 | 86.30 | 4.50 | 9.10 | 13.60 | SIPS | PANSS | |||
Susai et al., | 2 | 大洋洲 | <1 | 146 | 18.22 | 39 | 12.98 | CAARMS | BPRS/ SANS | SOFAS | ||||||
李佳 等, | 1 | 亚洲 | <1 | 30 | 29.85 | 57 | SIPS | PANSS | ||||||||
Tateno et al., | 4 | 亚洲 | 1~2 | 28 | 18.00 | 68 | 96.40 | 0, 00 | 3.60 | 0.00 | CAARMS | PANSS | GAF | |||
Salokangas et al., | 2 | 欧洲 | <1 | 59 | 25.00 | 53 | 13.20 | 11.40 | SIPS | GAF | ||||||
Patton et al., | 1 | 北美洲 | <1 | 54 | 18.60 | 59 | 12.40 | 8.00 | SIPS | SIPS | GFS | |||||
Paetzold et al., | 8 | 欧洲 | <1 | 48 | 23.60 | 46 | CAARMS | BPRS | GAF | |||||||
Kristensen et al., | 1 | 欧洲 | <1 | 88 | 23.80 | 47 | 99.10 | 2.80 | 23.90 | CAARMS | CAARMS/ SANS | SOFAS | ||||
Gifford et al., | 1 | 欧洲 | 1~2 | 57 | 22.82 | 63 | 14.72 | 21.50 | CAARMS | PANSS | GAF | |||||
Addington et al., | 2 | 北美洲 | <1 | 95 | 16.80 | 44 | 10.30 | SIPS | SIPS | GFS | ||||||
Aase et al., | 3 | 欧洲 | <1 | 31 | 17.00 | 42 | 100.00 | 0.00 | 0.00 | 24.50 | SIPS | SIPS | ||||
Leanza et al., | 1 | 欧洲 | >3 | 147 | 25.06 | 69 | 11.50 | 67.50 | 7.50 | 24.00 | SIPS | BPRS | GAF | |||
Glenthøj et al., | 1 | 欧洲 | <1 | 91 | 23.92 | 42 | 14.50 | 98.60 | 2.10 | 21.90 | CAARMS | SANS | GFS | |||
Berger et al., | 2 | 大洋洲 | <1 | 90 | 17.21 | 34 | CAARMS | BPRS/ SANS | SOFAS/ GFS | |||||||
Velthorst et al., | 4 | 北美洲 | <1 | 18 | 18.90 | 69 | 32.50 | SIPS | GFS | |||||||
Oribe et al., | 1 | 北美洲 | <1 | 18 | 21.20 | 50 | 13.10 | SIPS | SIPS | GAF | ||||||
Goldsmith et al., | 2 | 北美洲 | <1 | 37 | 19.76 | 62 | SIPS | SIPS | ||||||||
Sanada et al., | 1 | 欧洲 | <1 | 12 | 22.20 | 55 | CAARMS | PANSS | FAST | |||||||
Masillo et al., | 1 | 欧洲 | 1~2 | 85 | 16.36 | 53 | 33.30 | 0.00 | 1.20 | 4.70 | SIPS | SIPS | ||||
Krakauer et al., | 1 | 欧洲 | <1 | 30 | 24.07 | 43 | 100.00 | 3.30 | 53.30 | 0.00 | CAARMS | CAARMS/SANS | SOFAS | |||
Koshiyama et al., | 1 | 亚洲 | 1~2 | 20 | 21.40 | 45 | 13.16 | 46.70 | 15.20 | SIPS | PANSS | GAF | ||||
Kim et al., | 2 | 亚洲 | >3 | 7 | 19.80 | 65 | 12.10 | 35.00 | SIPS | SIPS | GAF | |||||
Katagiri et al., | 2 | 亚洲 | <1 | 14 | 24.48 | 36 | SIPS | SIPS | ||||||||
Saito et al., | 2 | 亚洲 | <1 | 6 | 22.93 | 28 | 11.59 | SIPS | SIPS | |||||||
Reniers et al., | 1 | 大洋洲 | >3 | 109 | 28.70 | 50 | 72.50 | 18.40 | 36.70 | CAARMS | BPRS/ SANS | GAF | ||||
Koshiyama et al., | 1 | 亚洲 | 1~2 | 16 | 20.60 | 44 | 8.50 | SIPS | PANSS | GAF | ||||||
Cotter et al., | 4 | 欧洲 | >3 | 184 | 18.50 | 45 | 79.80 | 11.40 | 26.60 | CAARMS | BPRS/SANS/HAM-A/ HAM-D | QLS | ||||
Bernard et al., | 1 | 北美洲 | <1 | 26 | 18.70 | 69 | SIPS | SIPS | ||||||||
陈发展 等, 2016 | 1 | 亚洲 | <1 | 47 | 21.20 | 47 | 100.00 | 17.02 | SIPS | SIPS | ||||||
Shin et al., | 1 | 亚洲 | 1~2 | 47 | 19.30 | 70 | 12.00 | 8.50 | CAARMS | SIPS | GAF/SFS | |||||
Cropley et al., | 1 | 大洋洲 | >3 | 30 | 19.93 | 50 | 0.00 | CAARMS | BPRS/ SANS | GAF | ||||||
Carrión et al., | 1 | 北美洲 | 2~3 | 76 | 16.00 | 68 | 30.50 | SIPS | SIPS | GAF/GFS | ||||||
Yung et al., | 1 | 大洋洲 | >3 | 268 | 43 | CAARMS | ||||||||||
Lin et al., | 2 | 大洋洲 | >3 | 31 | 20.42 | 42 | 36.70 | CAARMS | BPRS/ SANS | |||||||
Kim et al., | 1 | 亚洲 | 1~2 | 45 | 19.30 | 73 | 12.00 | 40.90 | SIPS | SIPS | GAF | |||||
Allen et al., | 2 | 欧洲 | 1~2 | 18 | 21.11 | 61 | 100.00 | 16.70 | 11.10 | CAARMS | CAARMS | GAF | ||||
Ziermans et al., | 1 | 欧洲 | >3 | 41 | 15.20 | 63 | 86.00 | 3.00 | 0.00 | 53.00 | 19.50 | SIPS/BSABS-P | GAF | |||
Schultze-Lutter et al., | 2 | 欧洲 | 1~2 | 165 | 25.30 | 59 | 32.90 | CAARMS | SOFAS | |||||||
Morita et al., | 1 | 亚洲 | <1 | 27 | 25.30 | 30 | 100.00 | 25.90 | 59.30 | SIPS | SIPS | GAF | ||||
Meyer et al., | 2 | 北美洲 | <1 | 96 | 18.20 | 64 | 10.40 | SIPS | GFS | |||||||
Egerton et al., | 2 | 欧洲 | 1~2 | 22 | 23.80 | 50 | 11.80 | CAARMS | PANSS | GAF | ||||||
De Wit et al., | 2 | 欧洲 | >3 | 18 | 14.20 | 64 | 22.70 | SIPS | SIPS | |||||||
Lin et al., | 1 | 欧洲 | >3 | 325 | 19.13 | 47 | 80.20 | 13.60 | 28.70 | 24.90 | CAARMS | BPRS/SANS/HAM-D | GAF | |||
Perez et al., | 2 | 北美洲 | <1 | 60 | 18.80 | 71 | 88.80 | 9.20 | 34.70 | 32.30 | SIPS | SAPS/ SANS/SIPS | GAF | |||
Ziermans et al., | 1 | 欧洲 | 1~2 | 42 | 17.60 | 60 | SIPS | SIPS | GAF | |||||||
Yung et al., | 1 | 大洋洲 | <1 | 78 | CAARMS | BPRS/SANS | GAF | |||||||||
Velthorst et al., | 3 | 欧洲 | <1 | 37 | 19.19 | 66 | 25.70 | SIPS | SIPS | GAF | ||||||
Lin et al., | 2 | 欧洲 | >3 | 41 | 18.54 | 56 | 61.70 | 5.20 | 48.80 | SIPS | BPRS | GAF | ||||
Fusar-Poli et al., | 1 | 欧洲 | <1 | 15 | 24.36 | 53 | CAARMS | PANSS | GAF | |||||||
Addington et al., | 2 | 北美洲 | <1 | 111 | 18.00 | 56 | SIPS | SIPS | GAF | |||||||
Willhite et al., | 4 | 北美洲 | <1 | 25 | 17.80 | 10.40 | SIPS | SIPS | GAF |
表1 纳入文献特征
第一作者 及年份 | 效应量数 | 取样 地区 | 随访时间(年) | 样本量 | 年龄(岁) | 性别(男性比例%) | 教育程度(年) | CHR-P亚组 | 精神病转化率(%) | 诊断工具 | 症状评 估工具 | 功能评 估工具 | 文献质量 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
APS比例(%) | BLIPS比例(%) | GRD比例(%) | COGDIS比例(%) | |||||||||||||
Pelizza et al., | 4 | 欧洲 | <1 | 87 | 18.21 | 52 | 11.06 | 78.70 | 16.90 | 4.50 | 8.10 | CAARMS | PANSS | GAF/ HoNOS | ||
Zhang et al., | 2 | 亚洲 | 2~3 | 59 | 19.80 | 48 | 10.60 | 25.40 | SIPS | GAF | ||||||
Værnes et al., | 1 | 欧洲 | <1 | 32 | 19.90 | 66 | 11.70 | 75.00 | 3.10 | 37.40 | 12.50 | SIPS | SIPS | GAF | ||
Usui et al., | 1 | 亚洲 | 1~2 | 22 | 21.10 | 46 | 13.00 | 86.30 | 4.50 | 9.10 | 13.60 | SIPS | PANSS | |||
Susai et al., | 2 | 大洋洲 | <1 | 146 | 18.22 | 39 | 12.98 | CAARMS | BPRS/ SANS | SOFAS | ||||||
李佳 等, | 1 | 亚洲 | <1 | 30 | 29.85 | 57 | SIPS | PANSS | ||||||||
Tateno et al., | 4 | 亚洲 | 1~2 | 28 | 18.00 | 68 | 96.40 | 0, 00 | 3.60 | 0.00 | CAARMS | PANSS | GAF | |||
Salokangas et al., | 2 | 欧洲 | <1 | 59 | 25.00 | 53 | 13.20 | 11.40 | SIPS | GAF | ||||||
Patton et al., | 1 | 北美洲 | <1 | 54 | 18.60 | 59 | 12.40 | 8.00 | SIPS | SIPS | GFS | |||||
Paetzold et al., | 8 | 欧洲 | <1 | 48 | 23.60 | 46 | CAARMS | BPRS | GAF | |||||||
Kristensen et al., | 1 | 欧洲 | <1 | 88 | 23.80 | 47 | 99.10 | 2.80 | 23.90 | CAARMS | CAARMS/ SANS | SOFAS | ||||
Gifford et al., | 1 | 欧洲 | 1~2 | 57 | 22.82 | 63 | 14.72 | 21.50 | CAARMS | PANSS | GAF | |||||
Addington et al., | 2 | 北美洲 | <1 | 95 | 16.80 | 44 | 10.30 | SIPS | SIPS | GFS | ||||||
Aase et al., | 3 | 欧洲 | <1 | 31 | 17.00 | 42 | 100.00 | 0.00 | 0.00 | 24.50 | SIPS | SIPS | ||||
Leanza et al., | 1 | 欧洲 | >3 | 147 | 25.06 | 69 | 11.50 | 67.50 | 7.50 | 24.00 | SIPS | BPRS | GAF | |||
Glenthøj et al., | 1 | 欧洲 | <1 | 91 | 23.92 | 42 | 14.50 | 98.60 | 2.10 | 21.90 | CAARMS | SANS | GFS | |||
Berger et al., | 2 | 大洋洲 | <1 | 90 | 17.21 | 34 | CAARMS | BPRS/ SANS | SOFAS/ GFS | |||||||
Velthorst et al., | 4 | 北美洲 | <1 | 18 | 18.90 | 69 | 32.50 | SIPS | GFS | |||||||
Oribe et al., | 1 | 北美洲 | <1 | 18 | 21.20 | 50 | 13.10 | SIPS | SIPS | GAF | ||||||
Goldsmith et al., | 2 | 北美洲 | <1 | 37 | 19.76 | 62 | SIPS | SIPS | ||||||||
Sanada et al., | 1 | 欧洲 | <1 | 12 | 22.20 | 55 | CAARMS | PANSS | FAST | |||||||
Masillo et al., | 1 | 欧洲 | 1~2 | 85 | 16.36 | 53 | 33.30 | 0.00 | 1.20 | 4.70 | SIPS | SIPS | ||||
Krakauer et al., | 1 | 欧洲 | <1 | 30 | 24.07 | 43 | 100.00 | 3.30 | 53.30 | 0.00 | CAARMS | CAARMS/SANS | SOFAS | |||
Koshiyama et al., | 1 | 亚洲 | 1~2 | 20 | 21.40 | 45 | 13.16 | 46.70 | 15.20 | SIPS | PANSS | GAF | ||||
Kim et al., | 2 | 亚洲 | >3 | 7 | 19.80 | 65 | 12.10 | 35.00 | SIPS | SIPS | GAF | |||||
Katagiri et al., | 2 | 亚洲 | <1 | 14 | 24.48 | 36 | SIPS | SIPS | ||||||||
Saito et al., | 2 | 亚洲 | <1 | 6 | 22.93 | 28 | 11.59 | SIPS | SIPS | |||||||
Reniers et al., | 1 | 大洋洲 | >3 | 109 | 28.70 | 50 | 72.50 | 18.40 | 36.70 | CAARMS | BPRS/ SANS | GAF | ||||
Koshiyama et al., | 1 | 亚洲 | 1~2 | 16 | 20.60 | 44 | 8.50 | SIPS | PANSS | GAF | ||||||
Cotter et al., | 4 | 欧洲 | >3 | 184 | 18.50 | 45 | 79.80 | 11.40 | 26.60 | CAARMS | BPRS/SANS/HAM-A/ HAM-D | QLS | ||||
Bernard et al., | 1 | 北美洲 | <1 | 26 | 18.70 | 69 | SIPS | SIPS | ||||||||
陈发展 等, 2016 | 1 | 亚洲 | <1 | 47 | 21.20 | 47 | 100.00 | 17.02 | SIPS | SIPS | ||||||
Shin et al., | 1 | 亚洲 | 1~2 | 47 | 19.30 | 70 | 12.00 | 8.50 | CAARMS | SIPS | GAF/SFS | |||||
Cropley et al., | 1 | 大洋洲 | >3 | 30 | 19.93 | 50 | 0.00 | CAARMS | BPRS/ SANS | GAF | ||||||
Carrión et al., | 1 | 北美洲 | 2~3 | 76 | 16.00 | 68 | 30.50 | SIPS | SIPS | GAF/GFS | ||||||
Yung et al., | 1 | 大洋洲 | >3 | 268 | 43 | CAARMS | ||||||||||
Lin et al., | 2 | 大洋洲 | >3 | 31 | 20.42 | 42 | 36.70 | CAARMS | BPRS/ SANS | |||||||
Kim et al., | 1 | 亚洲 | 1~2 | 45 | 19.30 | 73 | 12.00 | 40.90 | SIPS | SIPS | GAF | |||||
Allen et al., | 2 | 欧洲 | 1~2 | 18 | 21.11 | 61 | 100.00 | 16.70 | 11.10 | CAARMS | CAARMS | GAF | ||||
Ziermans et al., | 1 | 欧洲 | >3 | 41 | 15.20 | 63 | 86.00 | 3.00 | 0.00 | 53.00 | 19.50 | SIPS/BSABS-P | GAF | |||
Schultze-Lutter et al., | 2 | 欧洲 | 1~2 | 165 | 25.30 | 59 | 32.90 | CAARMS | SOFAS | |||||||
Morita et al., | 1 | 亚洲 | <1 | 27 | 25.30 | 30 | 100.00 | 25.90 | 59.30 | SIPS | SIPS | GAF | ||||
Meyer et al., | 2 | 北美洲 | <1 | 96 | 18.20 | 64 | 10.40 | SIPS | GFS | |||||||
Egerton et al., | 2 | 欧洲 | 1~2 | 22 | 23.80 | 50 | 11.80 | CAARMS | PANSS | GAF | ||||||
De Wit et al., | 2 | 欧洲 | >3 | 18 | 14.20 | 64 | 22.70 | SIPS | SIPS | |||||||
Lin et al., | 1 | 欧洲 | >3 | 325 | 19.13 | 47 | 80.20 | 13.60 | 28.70 | 24.90 | CAARMS | BPRS/SANS/HAM-D | GAF | |||
Perez et al., | 2 | 北美洲 | <1 | 60 | 18.80 | 71 | 88.80 | 9.20 | 34.70 | 32.30 | SIPS | SAPS/ SANS/SIPS | GAF | |||
Ziermans et al., | 1 | 欧洲 | 1~2 | 42 | 17.60 | 60 | SIPS | SIPS | GAF | |||||||
Yung et al., | 1 | 大洋洲 | <1 | 78 | CAARMS | BPRS/SANS | GAF | |||||||||
Velthorst et al., | 3 | 欧洲 | <1 | 37 | 19.19 | 66 | 25.70 | SIPS | SIPS | GAF | ||||||
Lin et al., | 2 | 欧洲 | >3 | 41 | 18.54 | 56 | 61.70 | 5.20 | 48.80 | SIPS | BPRS | GAF | ||||
Fusar-Poli et al., | 1 | 欧洲 | <1 | 15 | 24.36 | 53 | CAARMS | PANSS | GAF | |||||||
Addington et al., | 2 | 北美洲 | <1 | 111 | 18.00 | 56 | SIPS | SIPS | GAF | |||||||
Willhite et al., | 4 | 北美洲 | <1 | 25 | 17.80 | 10.40 | SIPS | SIPS | GAF |
结果变量 | N | k | n | Hedges' g | 异质性检验 | 失安全系数 N | Eggers test p | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M | 95% CI | p | Q | p | 水平2 I2, % | 水平3 I2, % | p | number | ||||||
症状 | ||||||||||||||
轻微阳性症状 | 41 | 64 | 3456 | −0.78 | −1.12 | −0.45 | <0.001 | 1717.91 | <0.001 | 17.58 | 81.05 | <0.001 | 83056 | 0.26 |
阴性症状 | 43 | 67 | 3840 | −0.45 | −0.65 | −0.25 | <0.001 | 1315.13 | <0.001 | 23.36 | 73.82 | <0.001 | 7346 | 0.87 |
瓦解症状 | 13 | 21 | 877 | −0.40 | −0.78 | −0.02 | 0.042 | 1092.67 | <0.001 | 12.31 | 83.72 | <0.001 | 526 | 0.25 |
情感症状 | 7 | 13 | 1438 | −0.84 | −1.18 | −0.49 | <0.001 | 313.64 | <0.001 | 97.26 | 0.00 | <0.001 | 3721 | 0.22 |
一般精神病理症状 | 17 | 26 | 713 | −0.43 | −0.71 | −0.15 | <0.001 | 319.22 | <0.001 | 22.24 | 69.73 | <0.001 | 1328 | 0.04 |
功能 | ||||||||||||||
整体功能 | 35 | 64 | 4120 | 0.47 | 0.31 | 0.62 | <0.001 | 1339.67 | <0.001 | 86.28 | 10.36 | <0.001 | 6059 | 0.71 |
社会功能 | 9 | 16 | 1101 | 0.66 | −0.08 | 1.41 | 0.076 | 490.74 | <0.001 | 5.43 | 93.57 | <0.001 | 1490 | 0.14 |
角色功能 | 10 | 17 | 1207 | 0.28 | 0.12 | 0.45 | 0.002 | 213.82 | <0.001 | 91.00 | 0.00 | <0.001 | 631 | 0.52 |
表2 主效应分析结果
结果变量 | N | k | n | Hedges' g | 异质性检验 | 失安全系数 N | Eggers test p | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M | 95% CI | p | Q | p | 水平2 I2, % | 水平3 I2, % | p | number | ||||||
症状 | ||||||||||||||
轻微阳性症状 | 41 | 64 | 3456 | −0.78 | −1.12 | −0.45 | <0.001 | 1717.91 | <0.001 | 17.58 | 81.05 | <0.001 | 83056 | 0.26 |
阴性症状 | 43 | 67 | 3840 | −0.45 | −0.65 | −0.25 | <0.001 | 1315.13 | <0.001 | 23.36 | 73.82 | <0.001 | 7346 | 0.87 |
瓦解症状 | 13 | 21 | 877 | −0.40 | −0.78 | −0.02 | 0.042 | 1092.67 | <0.001 | 12.31 | 83.72 | <0.001 | 526 | 0.25 |
情感症状 | 7 | 13 | 1438 | −0.84 | −1.18 | −0.49 | <0.001 | 313.64 | <0.001 | 97.26 | 0.00 | <0.001 | 3721 | 0.22 |
一般精神病理症状 | 17 | 26 | 713 | −0.43 | −0.71 | −0.15 | <0.001 | 319.22 | <0.001 | 22.24 | 69.73 | <0.001 | 1328 | 0.04 |
功能 | ||||||||||||||
整体功能 | 35 | 64 | 4120 | 0.47 | 0.31 | 0.62 | <0.001 | 1339.67 | <0.001 | 86.28 | 10.36 | <0.001 | 6059 | 0.71 |
社会功能 | 9 | 16 | 1101 | 0.66 | −0.08 | 1.41 | 0.076 | 490.74 | <0.001 | 5.43 | 93.57 | <0.001 | 1490 | 0.14 |
角色功能 | 10 | 17 | 1207 | 0.28 | 0.12 | 0.45 | 0.002 | 213.82 | <0.001 | 91.00 | 0.00 | <0.001 | 631 | 0.52 |
结果 变量 | 调节变量 | N | b Coefficient | SE | Mean Hedges’ g | F (df1, df2) | 95% CI | p value | 水平2 方差 | 水平3 方差 | |
---|---|---|---|---|---|---|---|---|---|---|---|
轻微阳性症状 | <0.001 | <0.001 | |||||||||
年龄 | 63 | 0.09 | 0.05 | F (1, 61) = 3.62 | −0.01 | 0.19 | 0.062 | ||||
性别 | 59 | 0.01 | 0.01 | F (1, 57) = 0.29 | −0.02 | 0.03 | 0.592 | ||||
受教育程度 | 23 | 0.46 | 0.20 | F (1, 21) = 5.01 | 0.03 | 0.88 | 0.036 | ||||
发表年份 | 64 | −0.02 | 0.05 | F (1, 62) = 0.21 | −0.11 | 0.07 | 0.652 | ||||
文献质量 | 64 | −0.02 | 0.16 | F (1, 62) = 0.01 | −0.34 | 0.30 | 0.911 | ||||
APS比例 | 20 | −0.01 | 0.01 | F (1, 18) = 1.39 | −0.02 | 0.01 | 0.253 | ||||
BLIPS比例 | 17 | 0.02 | 0.02 | F (1, 15) = 0.80 | −0.02 | 0.06 | 0.384 | ||||
GRD比例 | 17 | 0.01 | 0.01 | F (1, 15) = 0.28 | −0.01 | 0.02 | 0.603 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 64 | F (3, 60) = 0.01 | 0.999 | ||||||||
1~2年 | −0.02 | −0.54 | 0.51 | 0.947 | |||||||
2~3年 | −0.05 | −2.35 | 2.25 | 0.966 | |||||||
3年以上 | −0.03 | −0.58 | 0.51 | 0.907 | |||||||
阴性症状 | <0.001 | <0.001 | |||||||||
年龄 | 66 | 0.01 | 0.03 | F (1, 64) = 0.21 | −0.05 | 0.08 | 0.650 | ||||
性别 | 62 | 0.00 | 0.01 | F (1, 60) = 0.36 | −0.01 | 0.02 | 0.549 | ||||
受教育程度 | 21 | 0.32 | 0.15 | F (1, 19) = 4.40 | 0.00 | 0.63 | 0.050 | ||||
发表年份 | 67 | −0.01 | 0.03 | F (1, 65) = 0.22 | −0.07 | 0.04 | 0.639 | ||||
文献质量 | 67 | −0.07 | 0.09 | F (1, 65) = 0.63 | −0.26 | 0.11 | 0.429 | ||||
APS比例 | 21 | −0.01 | 0.01 | F (1, 19) = 1.62 | −0.03 | 0.01 | 0.219 | ||||
BLIPS比例 | 18 | −0.00 | 0.02 | F (1, 16) = 0.02 | −0.05 | 0.05 | 0.887 | ||||
GRD比例 | 18 | 0.00 | 0.01 | F (1, 16) = 0.04 | −0.02 | 0.02 | 0.847 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 67 | F (3, 63) = 0.18 | 0.909 | ||||||||
1~2年 | 0.02 | −0.32 | 0.35 | 0.925 | |||||||
2~3年 | −0.25 | −1.65 | 1.145 | 0.719 | |||||||
3年以上 | −0.14 | −0.61 | 0.33 | 0.550 | |||||||
瓦解症状 | 0.002 | 0.017 | |||||||||
年龄 | 21 | −0.09 | 0.05 | F (1, 19) = 3.30 | −0.19 | 0.01 | 0.082 | ||||
性别 | 17 | −0.01 | 0.01 | F (1, 15) = 0.99 | −0.04 | 0.02 | 0.335 | ||||
受教育程度 | 13 | −0.27 | 0.13 | F (1, 11) = 4.41 | −0.55 | 0.01 | 0.060 | ||||
发表年份 | 21 | −0.03 | 0.04 | F (1, 19) = 0.49 | −0.12 | 0.06 | 0.494 | ||||
文献质量 | 21 | −0.15 | 0.18 | F (1, 19) = 0.70 | −0.53 | 0.23 | 0.413 | ||||
APS比例 | 7 | 0.00 | 0.01 | F (1, 5) = 0.10 | −0.03 | 0.04 | 0.769 | ||||
BLIPS比例 | 5 | 0.03 | 0.05 | F (1, 3) = 0.29 | −0.13 | 0.18 | 0.626 | ||||
GRD比例 | 6 | 0.00 | 0.02 | F (1, 4) = 0.00 | −0.05 | 0.05 | 0.979 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 21 | F (2, 18) = 0.76 | 0.481 | ||||||||
1~2年 | −0.04 | −0.67 | 0.58 | 0.892 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.38 | −1.07 | 0.30 | 0.256 | |||||||
一般精神病理症状 | 0.002 | 0.022 | |||||||||
年龄 | 26 | 0.03 | 0.04 | F (1, 24) = 0.63 | −0.05 | 0.11 | 0.434 | ||||
性别 | 22 | −0.01 | 0.01 | F (1, 20) = 0.72 | −0.03 | 0.01 | 0.405 | ||||
受教育程度 | 10 | 0.21 | 0.14 | F (1, 8) = 2.25 | −0.11 | 0.53 | 0.172 | ||||
发表年份 | 26 | 0.02 | 0.04 | F (1, 24) = 0.23 | −0.06 | 0.09 | 0.636 | ||||
文献质量 | 26 | 0.04 | 0.12 | F (1, 24) = 0.11 | −0.21 | 0.29 | 0.744 | ||||
APS比例 | 7 | −0.01 | 0.01 | F (1, 5) = 0.47 | −0.03 | 0.02 | 0.522 | ||||
BLIPS比例 | 4 | D.n.a. | |||||||||
GRD比例 | 5 | 0.02 | 0.01 | F (1, 3) = 3.68 | −0.01 | 0.04 | 0.151 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 25 | F (2, 22) = 0.28 | 0.761 | ||||||||
1~2年 | 0.12 | −0.43 | 0.66 | 0.941 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.14 | −0.89 | 0.60 | 0.696 | |||||||
情感症状 | <0.001 | 1.000 | |||||||||
年龄 | 13 | −0.15 | 0.05 | F (1, 11) = 8.49 | −0.26 | −0.04 | 0.014 | ||||
性别 | 13 | 0.000 | 0.02 | F (1, 11) = 0.00 | −0.05 | 0.05 | 0.988 | ||||
受教育程度 | 4 | D.n.a. | |||||||||
发表年份 | 13 | −0.03 | 0.04 | F (1, 11) = 0.54 | −2.41 | 2.83 | 0.616 | ||||
文献质量 | 13 | −0.12 | 0.12 | F (1, 11) = 1.05 | −0.39 | 0.14 | 0.327 | ||||
APS比例 | 9 | −0.05 | 0.01 | F (1, 7) = 28.75 | −0.08 | −0.03 | 0.001 | ||||
BLIPS比例 | 9 | 0.19 | 0.04 | F (1, 7) = 21.28 | 0.09 | 0.28 | 0.002 | ||||
GRD比例 | 8 | −0.02 | 0.03 | F (1, 6) = 0.33 | −0.08 | 0.05 | 0.586 | ||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 13 | F (2, 10) = 0.97 | 0.974 | ||||||||
1~2年 | −0.18 | −1.90 | 1.54 | 0.824 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.05 | −1.11 | 1.01 | 0.920 | |||||||
整体功能 | <0.001 | 0.485 | |||||||||
年龄 | 63 | −0.04 | 0.03 | F (1, 61) = 2.37 | −0.09 | 0.01 | 0.129 | ||||
性别 | 59 | 0.00 | 0.01 | F (1, 57) = 0.00 | −0.01 | 0.02 | 0.952 | ||||
受教育程度 | 22 | −0.07 | 0.11 | F (1, 20) = 0.39 | −0.29 | 0.16 | 0.540 | ||||
发表年份 | 64 | −0.02 | 0.02 | F (1, 62) = 2.23 | −0.06 | 0.01 | 0.141 | ||||
文献质量 | 60 | −0.14 | 0.07 | F (1, 58) = 3.56 | −0.29 | 0.01 | 0.064 | ||||
APS比例 | 16 | 0.02 | 0.01 | F (1, 14) = 2.71 | −0.01 | 0.05 | 0.122 | ||||
BLIPS比例 | 15 | 0.02 | 0.03 | F (1, 13) = 0.32 | −0.04 | 0.07 | 0.581 | ||||
GRD比例 | 15 | 0.01 | 0.01 | F (1, 13) = 0.43 | −0.01 | 0.02 | 0.523 | ||||
COGDIS比例 | 2 | D.n.a. | |||||||||
随访时间 | 64 | F (3, 60) = 0.54 | 0.655 | ||||||||
1~2年 | −0.06 | −0.40 | 0.28 | 0.714 | |||||||
2~3年 | 0.34 | −0.39 | 1.08 | 0.351 | |||||||
3年以上 | −0.14 | 0.53 | −0.59 | 0.308 | |||||||
社会功能 | <0.001 | <0.001 | |||||||||
年龄 | 16 | −0.13 | 0.18 | F (1, 14) = 0.55 | −0.51 | 0.25 | 0.471 | ||||
性别 | 16 | −0.03 | 0.02 | F (1, 14) = 1.97 | −0.07 | 0.02 | 0.182 | ||||
受教育程度 | 5 | D.n.a. | |||||||||
发表年份 | 16 | 0.09 | 0.13 | F (1, 14) = 0.49 | −0.19 | 0.37 | 0.495 | ||||
文献质量 | 16 | −0.16 | 0.39 | F (1, 14) = 0.18 | −0.99 | 0.66 | 0.678 | ||||
APS比例 | 3 | D.n.a. | |||||||||
BLIPS比例 | 2 | D.n.a. | |||||||||
GRD比例 | 2 | D.n.a. | |||||||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 16 | F (3, 12) = 0.06 | 0.978 | ||||||||
1~2年 | 0.02 | −0.81 | 0.85 | 0.955 | |||||||
2~3年 | −0.55 | −3.40 | 2.31 | 0.683 | |||||||
3年以上 | −0.15 | −2.97 | 2.67 | 0.911 | |||||||
角色功能 | <0.001 | 1.000 | |||||||||
年龄 | 17 | −0.01 | 0.05 | F (1, 15) = 0.02 | −0.11 | 0.10 | 0.894 | ||||
性别 | 17 | 0.00 | 0.01 | F (1, 15) = 0.12 | −0.01 | 0.02 | 0.737 | ||||
受教育程度 | 6 | D.n.a. | |||||||||
发表年份 | 17 | −0.04 | 0.03 | F (1, 15) = 2.33 | −0.09 | 0.02 | 0.148 | ||||
文献质量 | 17 | −0.00 | 0.08 | F (1, 15) = 0.00 | −0.17 | 0.16 | 0.978 | ||||
APS比例 | 3 | D.n.a. | |||||||||
BLIPS比例 | 2 | D.n.a. | |||||||||
GRD比例 | 2 | D.n.a. | |||||||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 17 | F (3, 13) = 0.12 | 0.947 | ||||||||
1~2年 | −0.00 | −0.50 | 0.49 | 0.996 | |||||||
2~3年 | −0.02 | −0.80 | 0.75 | 0.949 | |||||||
3年以上 | 0.15 | −0.42 | 0.72 | 0.575 |
表3 CHR-P人群症状和功能纵向变化的调节效应检验结果
结果 变量 | 调节变量 | N | b Coefficient | SE | Mean Hedges’ g | F (df1, df2) | 95% CI | p value | 水平2 方差 | 水平3 方差 | |
---|---|---|---|---|---|---|---|---|---|---|---|
轻微阳性症状 | <0.001 | <0.001 | |||||||||
年龄 | 63 | 0.09 | 0.05 | F (1, 61) = 3.62 | −0.01 | 0.19 | 0.062 | ||||
性别 | 59 | 0.01 | 0.01 | F (1, 57) = 0.29 | −0.02 | 0.03 | 0.592 | ||||
受教育程度 | 23 | 0.46 | 0.20 | F (1, 21) = 5.01 | 0.03 | 0.88 | 0.036 | ||||
发表年份 | 64 | −0.02 | 0.05 | F (1, 62) = 0.21 | −0.11 | 0.07 | 0.652 | ||||
文献质量 | 64 | −0.02 | 0.16 | F (1, 62) = 0.01 | −0.34 | 0.30 | 0.911 | ||||
APS比例 | 20 | −0.01 | 0.01 | F (1, 18) = 1.39 | −0.02 | 0.01 | 0.253 | ||||
BLIPS比例 | 17 | 0.02 | 0.02 | F (1, 15) = 0.80 | −0.02 | 0.06 | 0.384 | ||||
GRD比例 | 17 | 0.01 | 0.01 | F (1, 15) = 0.28 | −0.01 | 0.02 | 0.603 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 64 | F (3, 60) = 0.01 | 0.999 | ||||||||
1~2年 | −0.02 | −0.54 | 0.51 | 0.947 | |||||||
2~3年 | −0.05 | −2.35 | 2.25 | 0.966 | |||||||
3年以上 | −0.03 | −0.58 | 0.51 | 0.907 | |||||||
阴性症状 | <0.001 | <0.001 | |||||||||
年龄 | 66 | 0.01 | 0.03 | F (1, 64) = 0.21 | −0.05 | 0.08 | 0.650 | ||||
性别 | 62 | 0.00 | 0.01 | F (1, 60) = 0.36 | −0.01 | 0.02 | 0.549 | ||||
受教育程度 | 21 | 0.32 | 0.15 | F (1, 19) = 4.40 | 0.00 | 0.63 | 0.050 | ||||
发表年份 | 67 | −0.01 | 0.03 | F (1, 65) = 0.22 | −0.07 | 0.04 | 0.639 | ||||
文献质量 | 67 | −0.07 | 0.09 | F (1, 65) = 0.63 | −0.26 | 0.11 | 0.429 | ||||
APS比例 | 21 | −0.01 | 0.01 | F (1, 19) = 1.62 | −0.03 | 0.01 | 0.219 | ||||
BLIPS比例 | 18 | −0.00 | 0.02 | F (1, 16) = 0.02 | −0.05 | 0.05 | 0.887 | ||||
GRD比例 | 18 | 0.00 | 0.01 | F (1, 16) = 0.04 | −0.02 | 0.02 | 0.847 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 67 | F (3, 63) = 0.18 | 0.909 | ||||||||
1~2年 | 0.02 | −0.32 | 0.35 | 0.925 | |||||||
2~3年 | −0.25 | −1.65 | 1.145 | 0.719 | |||||||
3年以上 | −0.14 | −0.61 | 0.33 | 0.550 | |||||||
瓦解症状 | 0.002 | 0.017 | |||||||||
年龄 | 21 | −0.09 | 0.05 | F (1, 19) = 3.30 | −0.19 | 0.01 | 0.082 | ||||
性别 | 17 | −0.01 | 0.01 | F (1, 15) = 0.99 | −0.04 | 0.02 | 0.335 | ||||
受教育程度 | 13 | −0.27 | 0.13 | F (1, 11) = 4.41 | −0.55 | 0.01 | 0.060 | ||||
发表年份 | 21 | −0.03 | 0.04 | F (1, 19) = 0.49 | −0.12 | 0.06 | 0.494 | ||||
文献质量 | 21 | −0.15 | 0.18 | F (1, 19) = 0.70 | −0.53 | 0.23 | 0.413 | ||||
APS比例 | 7 | 0.00 | 0.01 | F (1, 5) = 0.10 | −0.03 | 0.04 | 0.769 | ||||
BLIPS比例 | 5 | 0.03 | 0.05 | F (1, 3) = 0.29 | −0.13 | 0.18 | 0.626 | ||||
GRD比例 | 6 | 0.00 | 0.02 | F (1, 4) = 0.00 | −0.05 | 0.05 | 0.979 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 21 | F (2, 18) = 0.76 | 0.481 | ||||||||
1~2年 | −0.04 | −0.67 | 0.58 | 0.892 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.38 | −1.07 | 0.30 | 0.256 | |||||||
一般精神病理症状 | 0.002 | 0.022 | |||||||||
年龄 | 26 | 0.03 | 0.04 | F (1, 24) = 0.63 | −0.05 | 0.11 | 0.434 | ||||
性别 | 22 | −0.01 | 0.01 | F (1, 20) = 0.72 | −0.03 | 0.01 | 0.405 | ||||
受教育程度 | 10 | 0.21 | 0.14 | F (1, 8) = 2.25 | −0.11 | 0.53 | 0.172 | ||||
发表年份 | 26 | 0.02 | 0.04 | F (1, 24) = 0.23 | −0.06 | 0.09 | 0.636 | ||||
文献质量 | 26 | 0.04 | 0.12 | F (1, 24) = 0.11 | −0.21 | 0.29 | 0.744 | ||||
APS比例 | 7 | −0.01 | 0.01 | F (1, 5) = 0.47 | −0.03 | 0.02 | 0.522 | ||||
BLIPS比例 | 4 | D.n.a. | |||||||||
GRD比例 | 5 | 0.02 | 0.01 | F (1, 3) = 3.68 | −0.01 | 0.04 | 0.151 | ||||
COGDIS比例 | 1 | D.n.a. | |||||||||
随访时间 | 25 | F (2, 22) = 0.28 | 0.761 | ||||||||
1~2年 | 0.12 | −0.43 | 0.66 | 0.941 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.14 | −0.89 | 0.60 | 0.696 | |||||||
情感症状 | <0.001 | 1.000 | |||||||||
年龄 | 13 | −0.15 | 0.05 | F (1, 11) = 8.49 | −0.26 | −0.04 | 0.014 | ||||
性别 | 13 | 0.000 | 0.02 | F (1, 11) = 0.00 | −0.05 | 0.05 | 0.988 | ||||
受教育程度 | 4 | D.n.a. | |||||||||
发表年份 | 13 | −0.03 | 0.04 | F (1, 11) = 0.54 | −2.41 | 2.83 | 0.616 | ||||
文献质量 | 13 | −0.12 | 0.12 | F (1, 11) = 1.05 | −0.39 | 0.14 | 0.327 | ||||
APS比例 | 9 | −0.05 | 0.01 | F (1, 7) = 28.75 | −0.08 | −0.03 | 0.001 | ||||
BLIPS比例 | 9 | 0.19 | 0.04 | F (1, 7) = 21.28 | 0.09 | 0.28 | 0.002 | ||||
GRD比例 | 8 | −0.02 | 0.03 | F (1, 6) = 0.33 | −0.08 | 0.05 | 0.586 | ||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 13 | F (2, 10) = 0.97 | 0.974 | ||||||||
1~2年 | −0.18 | −1.90 | 1.54 | 0.824 | |||||||
2~3年 | D.n.a. | ||||||||||
3年以上 | −0.05 | −1.11 | 1.01 | 0.920 | |||||||
整体功能 | <0.001 | 0.485 | |||||||||
年龄 | 63 | −0.04 | 0.03 | F (1, 61) = 2.37 | −0.09 | 0.01 | 0.129 | ||||
性别 | 59 | 0.00 | 0.01 | F (1, 57) = 0.00 | −0.01 | 0.02 | 0.952 | ||||
受教育程度 | 22 | −0.07 | 0.11 | F (1, 20) = 0.39 | −0.29 | 0.16 | 0.540 | ||||
发表年份 | 64 | −0.02 | 0.02 | F (1, 62) = 2.23 | −0.06 | 0.01 | 0.141 | ||||
文献质量 | 60 | −0.14 | 0.07 | F (1, 58) = 3.56 | −0.29 | 0.01 | 0.064 | ||||
APS比例 | 16 | 0.02 | 0.01 | F (1, 14) = 2.71 | −0.01 | 0.05 | 0.122 | ||||
BLIPS比例 | 15 | 0.02 | 0.03 | F (1, 13) = 0.32 | −0.04 | 0.07 | 0.581 | ||||
GRD比例 | 15 | 0.01 | 0.01 | F (1, 13) = 0.43 | −0.01 | 0.02 | 0.523 | ||||
COGDIS比例 | 2 | D.n.a. | |||||||||
随访时间 | 64 | F (3, 60) = 0.54 | 0.655 | ||||||||
1~2年 | −0.06 | −0.40 | 0.28 | 0.714 | |||||||
2~3年 | 0.34 | −0.39 | 1.08 | 0.351 | |||||||
3年以上 | −0.14 | 0.53 | −0.59 | 0.308 | |||||||
社会功能 | <0.001 | <0.001 | |||||||||
年龄 | 16 | −0.13 | 0.18 | F (1, 14) = 0.55 | −0.51 | 0.25 | 0.471 | ||||
性别 | 16 | −0.03 | 0.02 | F (1, 14) = 1.97 | −0.07 | 0.02 | 0.182 | ||||
受教育程度 | 5 | D.n.a. | |||||||||
发表年份 | 16 | 0.09 | 0.13 | F (1, 14) = 0.49 | −0.19 | 0.37 | 0.495 | ||||
文献质量 | 16 | −0.16 | 0.39 | F (1, 14) = 0.18 | −0.99 | 0.66 | 0.678 | ||||
APS比例 | 3 | D.n.a. | |||||||||
BLIPS比例 | 2 | D.n.a. | |||||||||
GRD比例 | 2 | D.n.a. | |||||||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 16 | F (3, 12) = 0.06 | 0.978 | ||||||||
1~2年 | 0.02 | −0.81 | 0.85 | 0.955 | |||||||
2~3年 | −0.55 | −3.40 | 2.31 | 0.683 | |||||||
3年以上 | −0.15 | −2.97 | 2.67 | 0.911 | |||||||
角色功能 | <0.001 | 1.000 | |||||||||
年龄 | 17 | −0.01 | 0.05 | F (1, 15) = 0.02 | −0.11 | 0.10 | 0.894 | ||||
性别 | 17 | 0.00 | 0.01 | F (1, 15) = 0.12 | −0.01 | 0.02 | 0.737 | ||||
受教育程度 | 6 | D.n.a. | |||||||||
发表年份 | 17 | −0.04 | 0.03 | F (1, 15) = 2.33 | −0.09 | 0.02 | 0.148 | ||||
文献质量 | 17 | −0.00 | 0.08 | F (1, 15) = 0.00 | −0.17 | 0.16 | 0.978 | ||||
APS比例 | 3 | D.n.a. | |||||||||
BLIPS比例 | 2 | D.n.a. | |||||||||
GRD比例 | 2 | D.n.a. | |||||||||
COGDIS比例 | 0 | D.n.a. | |||||||||
随访时间 | 17 | F (3, 13) = 0.12 | 0.947 | ||||||||
1~2年 | −0.00 | −0.50 | 0.49 | 0.996 | |||||||
2~3年 | −0.02 | −0.80 | 0.75 | 0.949 | |||||||
3年以上 | 0.15 | −0.42 | 0.72 | 0.575 |
调节变量 | b Coefficient | 95% CI | p value | |
---|---|---|---|---|
Intercept | 6.28 | 1.34 | 11.23 | 0.02 |
年龄 | −0.24 | −0.40 | −0.07 | 0.01 |
APS比例 | −0.03 | −0.07 | 0.01 | 0.1 |
BLIPS比例 | −0.02 | −0.10 | 0.06 | 0.53 |
多重回归模型 | F (3, 5) = 5.79 | 0.04 |
表4 情感症状的多重回归分析
调节变量 | b Coefficient | 95% CI | p value | |
---|---|---|---|---|
Intercept | 6.28 | 1.34 | 11.23 | 0.02 |
年龄 | −0.24 | −0.40 | −0.07 | 0.01 |
APS比例 | −0.03 | −0.07 | 0.01 | 0.1 |
BLIPS比例 | −0.02 | −0.10 | 0.06 | 0.53 |
多重回归模型 | F (3, 5) = 5.79 | 0.04 |
*表示元分析纳入的文献 | |
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