ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2021, Vol. 29 ›› Issue (11): 2002-2012.doi: 10.3724/SP.J.1042.2021.02002

• 研究前沿 • 上一篇    下一篇


陈娟1, 何昊1,2, 杨丹丹1, 关青1,2()   

  1. 1深圳大学脑疾病与认知科学研究中心
    2深港脑科学创新研究院, 深圳 518060
  • 收稿日期:2020-11-10 出版日期:2021-11-15 发布日期:2021-09-23
  • 通讯作者: 关青
  • 基金资助:

Effects of repetitive transcranial magnetic stimulation on patients with mild cognitive impairment

CHEN Juan1, HE Hao1,2, YANG Dandan1, GUAN Qing1,2()   

  1. 1Center for Brain Diseases and Cognitive Sciences, Shenzhen University
    2Shenzhen-Hong Kong Institute of Brain Science - Shenzhen Fundamental Research Institutions, Shenzhen 518060, China
  • Received:2020-11-10 Online:2021-11-15 Published:2021-09-23
  • Contact: GUAN Qing


轻度认知障碍(mild cognitive impairment, MCI)是介于正常认知老化和老年痴呆的中间状态, 目前尚无有效的药物治疗方案。重复经颅磁刺激(repetitive transcranial magnetic stimulation, rTMS)可通过诱导突触可塑性的改变来改善大脑的认知功能。对rTMS干预MCI认知功能的有效性及神经机制进行分析。未来研究应优化定位手段, 延长对干预效果的随访评估, 考察不同刺激参数和刺激靶区对干预有效性的影响, 以及结合脑成像技术来探索rTMS的干预机制。

关键词: 轻度认知障碍, 非药物干预, 经颅磁刺激(TMS)


Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia, which does not affect activities of daily living. Patients with MCI typically show deficits in memory, attention, executive function, language and speech, which are related to the altered connectivity of large-scale brain networks, such as salience network, frontal-parietal network, and default mode network. MCI is associated with an increased risk of Alzheimer’s disease, but there lacks effective pharmacologic therapy of MCI. Repetitive transcranial magnetic stimulation (rTMS) is widely applied to enhance cognitive functions by modulating synaptic plasticity. However, there is a lack of studies examining effects of rTMS on MCI, and no consensus on its effectiveness and mechanisms has been reached. To address this problem, a literature review was conducted by searching literature in databases of Web Of Science, PubMed, PsycINFO, China National Knowledge Infrastructure, and by assessing the quality of included studies using the Cochrane Collaboration’s tool.
The results showed that the studies included in this review had a low risk of bias. Performing high-frequency rTMS on inferior frontal cortex (IFG) and superior temporal cortex (STG) improved attention in patients with MCI, by increasing the excitability of the attention network. High-frequency rTMS of dorsolateral prefrontal cortex (dlPFC) improved executive function. rTMS-excitation of dlPFC and precuneus enhanced episodic memory in MCI patients, and its underlying mechanism might be that rTMS improved the encoding function of dlPFC and the retrieving function of ventral precuneus. Based on that the increasing activity of right dlPFC is associated with the decreasing activity of hippocampus, the inhibition of dlPFC improved long-term memory in patients with MCI. Conducting high-frequency rTMS on medial prefrontal cortex (mPFC) could strengthen the connectivity among neuronal subpopulations in mPFC, improving the short-term memory of patients with MCI. Based on the strong functional connectivity between posterior parietal cortex (PPC) and hippocampus, performing high-frequency rTMS on parietal cortex could activate hippocampus by the PPC-hippocampus connection, which improves associative memory of patients with MCI. High-frequency rTMS over prefrontal cortex (PFC) improved associative memory, which was related to the additional activation of right IFG and middle frontal gyrus, reflecting a compensatory mechanism in associative memory.
rTMS shows effects in improving attention, executive function, episodic memory, long-term and short-term memory, and associative memory in patients with MCI. The improving effects could keep for 30 days, 8 weeks, or 6 months. No significant adverse effects of rTMS were reported in these studies. The major strengths of this review included that the inclusion and the quality assessment of studies followed standard protocol, and that the examinations of the rTMS effects on MCI and its underlying mechanisms were conducted comprehensively in terms of the affected multiple cognitive domains. Future studies should optimize the localization for TMS, extend the evaluation period of intervention effects, and explore how rTMS works in the treatment of MCI combining with neuroimaging technologies.

Key words: mild cognitive impairment, nonpharmacological intervention, transcranial magnetic stimulation (TMS)