ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2015, Vol. 23 ›› Issue (7): 1196-1204.doi: 10.3724/SP.J.1042.2015.01196

• 研究前沿 • 上一篇    下一篇

自闭症谱系障碍者异常的大脑功能连接

张芬;王穗苹;杨娟华;冯刚毅   

  1. (华南师范大学心理应用研究中心/心理学院, 广州510631)
  • 收稿日期:2014-10-20 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 王穗苹, E-mail: suiping@scnu.edu.cn
  • 基金资助:

    广东省高等学校珠江学者岗位计划资助项目(2012), 教育部人文社科重点研究基地重大项目(10JJDXLX005)。

Atypical Brain Functional Connectivity in Autism Spectrum Disorders

ZHANG Fen; WANG Suiping; YANG Juanhua; FENG Gangyi   

  1. (Center for Studies of Psychological Application / School of Psychology, South China Normal University, Guangzhou 510631, China)
  • Received:2014-10-20 Online:2015-07-15 Published:2015-07-15
  • Contact: WANG Suiping, E-mail: suiping@scnu.edu.cn

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摘要：

自闭症谱系障碍(Autism spectrum disorders, ASD)是一种常见的神经发育障碍, ASD在社交、语言、行为等方面的障碍与其异常的大脑功能连接存在密切关系。与正常发育者相比, ASD大脑既表现出远距离功能连接不足, 也表现出局部功能连接过度增强。ASD这种异常的脑功能连接受到结构异常、扫描状态、个体发展、分析方法等多种因素的影响。未来的ASD脑机制研究中, 要综合分析脑功能与结构, 关注年龄发展变化, 并将任务状态、被试取样、数据分析标准等因素纳入考察。

关键词: 自闭症谱系障碍, 功能连接, 功能磁共振成像

Abstract:

Autism spectrum disorders (ASD) is a common neurodevelopmental disorder. These patients suffer from social, language, and behavioral disturbances, which are associated with abnormal functional connectivity of the brain. Compared with typically developing participants, autistic people show an abnormal brain pattern of cortical under-connectivity and local over-connectivity. This abnormal brain function connection is influenced by many factors, such as atypical brain structures, scanning state, individual development, and analysis methods. In order to better understand the potential mechanisms under autism brain connectivity, future research should examine both the brain structures and functions, and consider participants’ age, task status and other factors.

Key words: Autism Spectrum Disorders, Functional connectivity, fMRI