Abstract: In this study the synaptic mechanism of scopolamine-induced memory dysfunctionwas investigated in the brain,the changes of the structure parameters of Gray Isynaptic interface in the hippocampal CA3 area were quantitatively analyzed in micemodel of scopolamine-induced memory dysfunction,and the effect of scopolamine onthe incorporation of3 H-Leu into hippocampal symaptosomes was observed.The resultsshowed that scopolamine could induce the thickness of post-synaptic density (PSD)thinned down significantly(P<0.01),and reduced the incorporation of 3 H-Leu intohippocampal symaptosomes apparently (p<0.001).These results suggested that thescopolamine-included memory dysfunction may be based on the decrease ofsynaptosomal protein syntheses of cholinergic system,and the changes of the synapticstructural parameters in the brain.

Key words: scopolamine, synaptic structural parameters, hippocampal CA3 area, memory dysfunction