Please wait a minute...
  论文 本期目录 | 过刊浏览 | 高级检索 |
庄楚群1,2; 王文清1; 胡静初1; 张蔚欣1; 王鹏贵1; 郑希付1
(1华南师范大学心理学院, 广州 510631) (2广东广雅中学, 广州 510160)
The effect of compound stimulus to conditioned fear extinction in retrieval-extinction paradigm
ZHUANG Chuqun1,2; WANG Wenqing1; HU Jingchu1; ZHANG Weixin1; WANG Penggui1; ZHENG Xifu1
(1 School of Psychology, South China Normal University, Guangzhou 510631, China) (2 Guangdong Guangya High School, Guangzhou 510631, China)
全文: PDF(493 KB)   评审附件 (1 KB) 
输出: BibTeX | EndNote (RIS)      

情绪障碍治疗的关键在于消退条件性恐惧记忆, 研究证明基于记忆再巩固的提取−消退范式能有效消除或改写原有的恐惧记忆。本研究将提取−消退范式应用到更复杂的恐惧记忆中, 采用多感官复合刺激(声音+图片)作为条件刺激, 以皮电反应作为恐惧反应指标, 考察采用单个线索(声音或图片)、复合线索(声音+图片)进行提取−消退对条件性恐惧记忆的消退效果有何差异。结果表明:声音线索提取−消退组出现了自发恢复和重建效应, 图片提取−消退组只出现了重建效应, 复合刺激提取−消退组未出现自发恢复和重建效应。说明由复合刺激线索引发的条件性恐惧, 采用复合刺激中的单个较强线索或原有完整线索进行提取−消退, 对恐惧记忆的消退效果最好。

E-mail Alert
关键词 恐惧消退 提取−消退范式 复合刺激    

Fear memory could be a tremendous burden for anxiety disorders such as post-traumatic stress disorder and phobia. The formation of fear memory refers to the phenomenon wherein a neutral stimulus (conditioned stimulus, CS; e.g., a tone) that does not initially induce fear in an individual, begins to do so after it is repeatedly paired with an intrinsically aversive consequence (unconditioned stimulus, US; e.g., a shock). Recent evidences suggest that fear memories can be updated by presenting a single cue prior to extinction during the reconsolidation time window (ret+ext). However, real-life traumatic events are usually associated with multiple different cues, and sometimes more than one sensory modality (e.g. both auditory and visual cues). Here we hypothesize that complex fear memory can be disrupted by retrieval-extinction interference in reconsolidation time window. We addressed this hypothesis by using a modified ret-ext paradigm based on a three consecutive days' experiment. Skin-conductance response (SCR) served as the measurement of fear responses. Three groups of participants underwent fear conditioning by a discrimination paradigm with partial reinforcement (30%) in day1. For the fear conditioning, two colored squares and two tones were used, one square and one tone combination served as a compound conditioned stimulus (CS+) that paired with a mild shock to the wrist (unconditioned stimulus) on 38% of the trials, whereas the combination of the other square and the other tone was never paired with shock (CS−). A day later, Group T received a reminder trial of a tone (auditory part of the compound CS+), Group P received a reminder trial of a square (visual part of the compound CS+), and Group T+P received a reminder trial of the combination of tone and square (absolute same compound CS+ as day1). 10 minutes later, all three groups underwent extinction training in which the two conditioned stimuli were repeatedly presented without the unconditioned stimulus. Twenty-four hours later, all three groups underwent extinction again (re-extinction) to assess spontaneous fear recovery. Then, all three groups received 4 unsigned shocks (US), followed by a extinction session to assess reinstatement. Current results showed that the SCR were not significantly different among the three groups in fear conditioning of the first day (F(2,34) = 0.024, p = 0.98) and extinction of the second day (F(2,34) = 0.10, p = 0.91). In the third day, Group T showed increased SCR in spontaneous fear recovery (p < 0.001) and reinstatement test (p < 0.01), whereas Group P only showed increased SCR in reinstatement test (p < 0.01), but no spontaneous recovery (p > 0.05). And Group T+P did not showed increased SCR in spontaneous fear recovery (p > 0.05) or reinstatement test (p > 0.05). Our study provided evidence that the behavioral interference during reconsolidation time window (retrieval-extinction) can block the spontaneous recovery and reinstatement of fear memory. According to the results, we also demonstrated that the compound memory can be disrupted by interrupting the reconsolidation (using the stronger individual component). These findings provided insight into how compound fear memories encoded, and have clinical implications for future PTSD treatment.

Key wordsfear extinction    retrieval-extinction paradigm    compound CS
收稿日期: 2016-06-12      出版日期: 2017-03-25

国家自然科学基金项目(31371057), 国家社会科学基金重大项目(14ZDB259), 幸福广州心理服务与辅导基地资助。

通讯作者: 郑希付, E-mail:    
庄楚群;王文清;胡静初;张蔚欣;王鹏贵;郑希付. 提取−消退范式中复合刺激对恐惧消退的影响[J]. 心理学报, 10.3724/SP.J.1041.2017.00329.
ZHUANG Chuqun; WANG Wenqing; HU Jingchu; ZHANG Weixin; WANG Penggui; ZHENG Xifu. The effect of compound stimulus to conditioned fear extinction in retrieval-extinction paradigm. Acta Psychologica Sinica, 2017, 49(3): 329-335.
链接本文:      或
[1] 杜娟;曾祥星;郑希付;庄楚群. 非条件刺激降低再评估对条件性恐惧消退的影响[J]. 心理学报, 2015, 47(3): 344-352.
[2] 张昕,韩世辉. 大脑两半球与整体和局部性质的选择性加工[J]. , 2004, 36(05): 507-514.
[3] 韩世辉, 王,纯, 周,磊. 注意和非注意条件下的整体和局部性质加工[J]. , 2004, 36(04): 410-416.
[4] 韩世辉. 视觉信息加工中的整体优先性[J]. , 2000, 32(03): 337-347.
[5] 韩世辉,肖峰. 影响视觉复合刺激中整体和局部性质加工的几种因素[J]. , 1999, 31(03): 274-283.
Full text



版权所有 © 《心理学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发  技术支持