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   2011, Vol. 19 Issue (5) : 633-644     DOI:
研究构想 |
The Role of the Cortex-Dorsal Striatum Pathway in Morhpine-Induced Compulsive Drug Seeking and Taking Behaviors
BAI Yun-Jing;ZHENG Xi-Geng
The Institute of Psychology, Chinese Academy of Sciences; The Division of Mental Health and Behavior Genetics, Beijing 100101, China
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Abstract  Drug addiction is a chronic brain disease characterized by compulsive drug seeking and taking behaviors. From initially go-directed drug use to compulsive drug taking, the drug-seeking behavior in addicts becomes more and more habitual. Compulsive drug seeking and taking behaviors are habitual behaviors depending on dorsolateral striatum, and the impaired function of executive control of behavior by prefrontal cortex-dorsomedial striatum pathway, which leads to persistent control of behavior by sensorimotor cortex-dorsolateral striatum pathway, is an important neural mechanism underlying compulsive addicted behaviors. The study will establish the animal model of drug addiction and adopt behavioral, behavioral pharmacological and morphological techniques to discover the role of the cortex-striatum pathway in compulsive drug seeking and taking behaviors. The results may shed light on the possible molecular mechanisms involved in drug addiction.
Keywords compulsive drug-seeking behavior      dorsolateral striatum      prefrontal cortex      prefrontal-dorsomedial striatum pathway     
Corresponding Authors: BAI Yun-Jing   
Issue Date: 15 May 2011
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BAI Yun-Jing
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BAI Yun-Jing,ZHENG Xi-Geng. The Role of the Cortex-Dorsal Striatum Pathway in Morhpine-Induced Compulsive Drug Seeking and Taking Behaviors[J]. , 2011, 19(5): 633-644.
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http://journal.psych.ac.cn/xlkxjz/EN/     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2011/V19/I5/633
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