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Advances in Psychological Science    2020, Vol. 28 Issue (3) : 456-464     DOI: 10.3724/SP.J.1042.2020.00456
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Roles of oxytocin in maternal behavior of women with postpartum depression and its underlying neural mechanisms
DI Tianqi, HUANG Yujing, GAO Jun
School of Psychology, the Southwest University, Chongqing 400715, China
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Abstract  Postpartum depression is a complex phenomenon of severe depressive episodes that occur within a period of time after delivery. Evidences suggest that oxytocin is an important modulator of female reproductive functions including parturition, lactation and maternal behavior, while it also plays an important role in modulating the development of postpartum depression and the maintain of maternal behavior. In postpartum depression patients, the emotional and cognitive impairment might contribute to the impairment of maternal behavior. Oxytocin directly regulates maternal behavior through the mesolimbic dopamine system. Oxytocin acting on medial preoptic area (MPOA) to activate the pathway of ventral tegmental area (VTA)-nucleus accumbens (NAc) and thus modulate the secretion of dopamine in NAc. Finally, we point out that oxytocin mediates maternal behavior in postpartum depression is through its modulation of the serotoninergic system, and its interactions with other hormones. Future studies should focus on functional differences of oxytocin in the central nervous system and the effect of social support on oxytocin uses in postpartum depression.
Keywords oxytocin      postpartum depression      maternal behaviors      neural circuit mechanisms      neurochemical mechanisms     
ZTFLH:  B845  
Issue Date: 18 January 2020
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DI Tianqi
HUANG Yujing
GAO Jun
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DI Tianqi,HUANG Yujing,GAO Jun. Roles of oxytocin in maternal behavior of women with postpartum depression and its underlying neural mechanisms[J]. Advances in Psychological Science, 2020, 28(3): 456-464.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2020.00456     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2020/V28/I3/456
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