Please wait a minute...
Advances in Psychological Science    2016, Vol. 24 Issue (10) : 1583-1591     DOI: 10.3724/SP.J.1042.2016.01583
Regular Articles |
BDNF gene and depression
TIAN Xiangjuan; WANG Meiping
(School of Psychology, Shandong Normal University, Jinan 250014, China)
Download: PDF(372 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

It has been well documented that the etiology and development of depression have important genetic underpinnings. With the advancement of experimental methods of cellular and molecular biology and analysis techniques of molecular genetics, there is growing concern about BDNF gene, which relates to neural plasticity and found to be an important candidate gene of depression. Generally, existing studies had mainly explored the direct association between BDNF gene and depression, the interaction between BDNF gene and other genes, as well as the moderating effect of environmental factors on the association between BDNF gene and depression. However, the conclusions have been inconsistent and even contradictory in some cases. This might be due to the differences in research designs, indexes of environment measurement, methods of depression measurement, and participants’ ethnic backgrounds of extant studies. Future research should focus on such issues as multiple gene–environment effects on depression, the moderation effect of participants’ ethnicity, gender and age on the association between genes and depression, and the neural biological mechanisms underlying depression.

Keywords BDNF gene      depression      gene–environment interaction      hypothesis of brain-derived neurotrophic factor     
Corresponding Authors: WANG Meiping, E-mail: meiping76@126.com   
Issue Date: 15 October 2016
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
TIAN Xiangjuan
WANG Meiping
Cite this article:   
TIAN Xiangjuan,WANG Meiping. BDNF gene and depression[J]. Advances in Psychological Science, 2016, 24(10): 1583-1591.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.01583     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I10/1583
[1] JIN Yuchang, DING Meiyue.  Predictive factors and the neurophysiological mechanism of postpartum depression[J]. Advances in Psychological Science, 2017, 25(7): 1145-1161.
[2] LIN Xiaoxiao; LUO Fei; WANG Jingyan. Emotional circuit abnormalities and cognitive affective bias: Neuropsychological mechanisms of pain-depression comorbidity[J]. Advances in Psychological Science, 2016, 24(5): 725-738.
[3] CAO Yanmiao; WANG Meiping; CAO Cong; ZHANG Wenxin. The polygenic underpinnings of depression[J]. Advances in Psychological Science, 2016, 24(4): 525-535.
[4] ZHANG Ke; ZHAO Mei; LIN Wenjuan. The role of epigenetic regulation in stress-induced depression[J]. Advances in Psychological Science, 2016, 24(12): 1882-1888.
[5] LI Huanhuan; Xie Weizhen; LI Yongna. Neural Circuits of Orbitofrontal Cortex Involved in Suicidal Attempts Among Major Depression Patients[J]. Advances in Psychological Science, 2015, 23(7): 1187-1195.
[6] LIU Lei; ZHOU Renlai. An Important Neural Indicator of Measuring Depression: The Asymmetry of Resting Frontal Activity[J]. Advances in Psychological Science, 2015, 23(6): 1000-1008.
[7] ZHANG Pei; XIA Mian. Antidepressants Adherence and Its Contributing Factors for Patients with Depression[J]. Advances in Psychological Science, 2015, 23(6): 1009-1020.
[8] HE Zhenhong; ZHANG Dandan; LUO Yuejia. Mood-Congruent Cognitive Bias in Depressed Individuals[J]. Advances in Psychological Science, 2015, 23(12): 2118-2128.
[9] YU Bin; NIU Kaijun. Diet, Nutrition, and Depression[J]. Advances in Psychological Science, 2015, 23(12): 2107-2117.
[10] ZHANG Dashan; SHI Huiying; LIU Wei; QIU Jiang; FAN Fenghui. The Application of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Depression[J]. Advances in Psychological Science, 2015, 23(10): 1789-1798.
[11] LIU Wei; Li Haijiang; Qiu Jiang. The Disconnected Brain of Major Depression Disorder: Evidence from Graph Theory Analysis[J]. Advances in Psychological Science, 2015, 23(1): 85-92.
[12] ZHOU Lihua;CHEN Jian;LU Dali;LIU Xiaoqun;SU Linyan. Hopelessness and Hopefulness: Risk and Resilience to Hopelessness Depression from the Perspective of Cognitive Style[J]. Advances in Psychological Science, 2014, 22(6): 977-986.
[13] CAO Cong; CHEN Guanghui; WANG Meiping; CAO Yanmiao; ZHANG Wenxin. Association between MAOA Gene and Depression[J]. Advances in Psychological Science, 2014, 22(12): 1899-1910.
[14] CAO Yanmiao;WANG Meiping;CAO Cong;CHEN Guanghui;ZHANG Wenxin. Gender Differences in the Genetic Underpinning of Depression[J]. Advances in Psychological Science, 2013, 21(9): 1605-1616.
[15] TANG Mingming;LIN Wenjuan. Habenula: New Approach to Study and Treatment of Depression[J]. Advances in Psychological Science, 2013, 21(7): 1213-1219.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Advances in Psychological Science
Support by Beijing Magtech