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Advances in Psychological Science    2013, Vol. 21 Issue (9) : 1605-1616     DOI: 10.3724/SP.J.1042.2013.01605
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Gender Differences in the Genetic Underpinning of Depression
CAO Yanmiao;WANG Meiping;CAO Cong;CHEN Guanghui;ZHANG Wenxin
(School of Psychology, Shandong Normal University, Jinan 250014, China)
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Abstract  Human depression has complex genetic underpinnings which vary across genders. These gender differences exist both in forms of direct effects of genes and gene-environment interactions on depression. The present paper systematically reviewed the extant literature of both twin studies and molecular genetic studies in the realm and discussed the possible causes of gender differences in the association between genetic variants and depression. Possible explanations provided included gender differences in sex hormones, sensitivity to environment and intermediate phenotype. Previous studies have highligted the value in taking a developmental perspective in investigating genetic effects on depression, future research should employ longitudinal design to reveal the developmental changes of the effect of genetic variants and their interactions with enviroment on depression. Besides, gender differences in genetic susceptibility to depression remain an important direction for future research.
Keywords depression      genetics      environment      gender difference     
Corresponding Authors: ZHANG Wenxin   
Issue Date: 15 September 2013
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CAO Yanmiao
WANG Meiping
CAO Cong
CHEN Guanghui
ZHANG Wenxin
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CAO Yanmiao,WANG Meiping,CAO Cong, et al. Gender Differences in the Genetic Underpinning of Depression[J]. Advances in Psychological Science, 2013, 21(9): 1605-1616.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2013.01605     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2013/V21/I9/1605
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