ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 2002, Vol. 34 ›› Issue (03): 75-80.

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以兔抗鼠淋巴细胞血清为非条件刺激的条件性免疫抑制

林文娟;陈极寰;A.J.Husband   

  1. 中国科学院心理研究所脑-行为研究中心,中国科学院心理研究所脑-行为研究中心,DepartmentofVeterinaryPathology 北京100101 ,北京100101 ,UniversityofSydney,NSW2006
  • 出版日期:2002-06-25 发布日期:2002-06-25
  • 通讯作者: 林文娟

CONDITIONED IMMUNOSUPPRESSION TO RABBIT ANTI-RAT LYMPHOCYTE SERUM IN RATS

Lin Wenjuan, Chen Jihuan (Brain Behavior Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101) Alan Husband (Department of Veterinary Pathology, University of Sydney, NSW 2006)   

  • Published:2002-06-25 Online:2002-06-25

摘要： 采用一种生物类免疫抑制剂—兔抗鼠淋巴血清 (rabbitanti ratlymphocyteserum ,ALS)为非条件刺激(UCS)、糖精水为条件刺激 (CS) ,以双瓶给水法置于鼠笼前端饮用偏好侧。在一次性CS—UCS结合训练后 ,单独再次给予CS ,使卵清蛋白 (OVA)免疫过的大鼠表现出脾淋巴细胞对有丝分裂原PWM的增殖反应降低、血抗OVA抗体的总量及脾内抗OVA抗体生成细胞的减少。但动物未表现出条件性味觉厌恶的行为反应。这些结果表明条件性免疫抑制与味觉厌恶性行为条件反射没有必然联系 ,并非是厌恶行为反应或情绪应激的伴随产物 ,UCS也并非必需具有感觉的毒副作用。条件性免疫抑制是脑高级神经活动调节免疫功能的结果

关键词: 兔抗鼠淋巴细胞血清, 味觉厌恶, 条件刺激, 条件反射性免疫抑制, 大鼠

Abstract: Conditioned immunosupression of rabbit anti rat lymphocyte serum (ALS), a biological immunosuppressant, was assessed in the experiment using a two bottle preference drinking procedure. The data showed that ovalbumine (OVA) immunized rats conditioned by pairing a novel saccharin solution (CS) with an ip injection of ALS (UCS) showed conditioned immunosuppression in vitro PWM induced spleen proliferation and in total anti OVA Ig antibody production as well as in anti OVA containing cells in spleen, but did not show conditioned taste aversion. These results suggested that there was no association between the conditioned taste aversion and the conditioned immunosuppressive responses and that the conditioned immunosuppression was not the concomitant of behavioral suppression, but the result of the CS UCS associative learning mediated by the central nervous system.

Key words: anti rat lymphocyte serum, conditioned taste aversion, rat, conditioned immunosuppression