ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 2000, Vol. 32 ›› Issue (4): 428-432.

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电击信号应激对大鼠体液免疫及内分泌功能的影响

邵枫;林文娟;王玮雯;郑丽   

  1. 中国科学院心理研究所脑-行为研究中心!北京 100101,中国科学院心理研究所脑-行为研究中心!北京 100101,中国科学院心理研究所脑-行为研究中心!北京 100101,中国科学院心理研究所脑-行为研究中心!北京 100101
  • 出版日期:2000-12-25 发布日期:2000-12-25
  • 通讯作者: 邵枫

MODULATION OF THE PRIMARY HUMORAL IMMUNITY BY EMOTIONAL STRESS

Shao Feng Lin Wenjuan Wang Weiwen Zheng Li (Institute of Psychology, Chinese Academy of Sciences, Beijing 100101)   

  • Published:2000-12-25 Online:2000-12-25

摘要: 研究了足电击及以电击装置为信号刺激所诱发的情绪应激对大鼠原发性体液免疫反应及内分泌的影响。 结果表明每天10分钟,共6天的足电击对大鼠抗特异性抗原OVA的原发性体液免疫反应无明显作用,而此电击作 用结合每天10分钟,共8天的情绪应激则可显著降低大鼠体液免疫反应及脾脏指数。同时该应激可显著提高大鼠 血儿茶酚胶和皮质酮水平。该研究证明了情绪应激对大鼠体液免疫功能的调节作用,并对交感神经系统和下丘脑- 垂体-肾上腺(HPA)轴在其中所起的作用进行了初步探讨。

关键词: 情绪应激, 原发性体液免疫反应, 儿茶酚胺, 皮质酮

Abstract: The emotional stress induced by footshock apparatus as signal stimuli was investigated for its effect on the primary humoral immunity and endocrine response of rats. The reactivity of primary humoral immunity was tested by determing the value of specific IgG antibody after immunization with OVA, and the value of catecholamine and corticosterone were used to measure the endocrine response. Our results showed that ten minutes per day, six days uncontrolled footshocks could not decrease significantly the primary humoral immune response of rats, but footshocks and emotional stress together could decrease the anti-OVA IgG antibody production and spleen index significantly. At the same time, emotional stress could increase the levels of catecholamine and corticosterone significantly. It was concluded that immune and endocrine system were capable of reacting specifically to psychological stimuli.

Key words: emotional stress, primary humoral immunity, catecholamine, corticosterone