高压氧对小鼠学习记忆及脑细胞形态结构的影响

心理学报 ›› 2000, Vol. 32 ›› Issue (1): 91-94.

高压氧对小鼠学习记忆及脑细胞形态结构的影响

徐晓虹;郭丹;章子贵;吴馥梅

浙江师范大学生物系!金华３２１００４,南京海军高等医学专科学校,浙江师范大学生物系!金华３２１００４,南京大学生物科学与技术系!南京２１００９２

发布日期:2000-03-25 出版日期:2000-03-25
通讯作者: 徐晓虹

EFFECTS OF HYPERBARIC OXYGEN ON THE LEARNING-MEMORY BEHAVIOR AND CELLULAR MORPHOMETRIC CHARACTER IN RELATED BRAIN AREAS OF YOUNG MICE

Xu Xiaohong; Guo Dan; Zhang Zigui(Biology Deparment of Zhenjiang Normal University,Jinhua 321004)Wu Fumei(Dept. of Biological Sciences and Technique,Nanjing University Nanjing 210093)

Online:2000-03-25 Published:2000-03-25

摘要/Abstract

摘要： 实验用两种行为模型（旷场行为模型和Ｙ－迷宫分辨学习模型）观察了幼龄小鼠在不同压力的高压氧处理后，对新异环境的探究行为和自发活动情况，以及学习记忆能力的变化；并用ＸＹ－生物医学电脑图像分析仪分析了与学习记忆相关的脑区（大脑皮层、海马）神经元密度，细胞核面积，胞核／胞浆比值的变化。结果表明：（１）与对照组相比，吸０.１ＭＰａ高压氧的幼鼠学习记忆能力明显提高，相关脑区的神经元密度、细胞核面积、胞核／浆比均显著增加。（２）吸０.２５ＭＰａ高压氧的幼鼠学习记忆能力与对照组相比无明显变化，但其在新异环境中的自发行为明显减少。提示：慢性吸入０.１ＭＰａ高压氧有利于促进幼鼠脑的生长发育，增强脑功能活动。

关键词: 高压氧, 学习记忆行为, 大脑皮层, 海马, 形态测量

Abstract: In the present investigation, the spontaneous activity, the behavior of learning and memory of 20-dayold mice were studied by using open field and Y-maze after hyperbaric oxygen treatment. Theneuronal density, cell nuclear area and the ratio of nuclear and plasma of memory-related brain areas(cerebral cortex, hippocampus) of these mice were measured by using computer image analysis system.The results ale as follows: (1) Compared with the control group, 0.1 MPa hyperbaric oxygen canremarkably ameliorate the learning and memory retention of young mice. (2) The neuronal density, cellnuclear area and the ratio of nuclear and plasma of the mice were significantly increased after 0.1 MPahyperbaric oxygen treatment. Compared with the control group, 0.25 MPa hyperbaric oxygen canremarkably decreace ace the spontaneous activity of young mice. These results indicated that 0.1 MPahyperbaric oxygen treatment not only could enhance brain development but also improve the function oflearning-memory of young mice.

Key words: hyperbaric oxygen, learning and memory behavior, cerebral cortex, hippocampus, morphometry

徐晓虹,郭丹,章子贵,吴馥梅. (2000). 高压氧对小鼠学习记忆及脑细胞形态结构的影响. 心理学报, 32(1), 91-94.

Xu Xiaohong, Guo Dan, Zhang Zigui(Biology Deparment of Zhenjiang Normal University,Jinhua 321004)Wu Fumei(Dept. of Biological Sciences and Technique,Nanjing University Nanjing 210093). (2000). EFFECTS OF HYPERBARIC OXYGEN ON THE LEARNING-MEMORY BEHAVIOR AND CELLULAR MORPHOMETRIC CHARACTER IN RELATED BRAIN AREAS OF YOUNG MICE. , 32(1), 91-94.

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