视觉系统的“适应-训练双向性”：猫外膝状体、17区、21a区短时程可塑性的层级递进研究

心理科学进展 ›› 2019, Vol. 27 ›› Issue (suppl.): 56-56.

视觉系统的“适应-训练双向性”：猫外膝状体、17区、21a区短时程可塑性的层级递进研究

冯尚, 崔志畅, 俞洪波^a

^a复旦大学生命科学学院视觉研究实验室,上海市邯郸路220号,中国,200433

出版日期:2019-08-26 发布日期:2022-03-21

“Adaptation-Training Switch” in Vision System: Hierarchical Progressive Short-term Bi-directional Plasticity in dLGN, Area 17 and Area 21a of Cats

Shang FENG, Zhichang CUI, Hongbo YU^a

^a Vision Research Laboratory, School of Life Sciences, Fudan University, Handan Road 220, Yangpu Dist., Shanghai, China, 200433

Online:2019-08-26 Published:2022-03-21

摘要/Abstract

摘要： 目的：短时程神经可塑性在学习与工作记忆中扮演关键角色。对不同脑区的视觉适应研究揭示了功能递进的短时程可塑性模式,这有助于理解视觉信息在通路层次间的动态处理机制。
方法：结合“倾向性适应”范式与在体电生理单细胞记录,在猫外膝状体、17区和21a区均发现单细胞层面的适应抑制与训练增强的双向切换。
结果：诱发训练增强所需的训练方向概率倍数范围：在外膝状体为8~80;在17区为2~8;在21a区为1~4。低于下限无法诱发反应特性变化,高于上限则可诱发适应抑制。进一步研究提示,单个细胞对适应与训练的双向性而言,具有刺激参数特异性和细胞类型相关性。
结论：沿外膝体和视觉腹侧通路,短时程双向可塑性的模式显示出渐近性变化,这提示了视觉系统中,视觉信息处理机制中共存着的层次间传递以及层次内的独特性。

关键词: 短时程可塑性, 倾向性适应, 视觉腹侧通路, 外侧膝状体

Abstract: PURPOSE: Short-term neural plasticity plays a key role in learning and working memory. Investigation on visual adaptation across different brain regions reveals interesting functional progressive short-term plasticity patterns, which will be helpful to understand how information is processed dynamically along visual streams.
METHODS: Combining biased adaptation protocol and in vivo electrophysiology single unit recording, we observed bi-directional switch of adaptive depression and training potentiation at single-cell level in dLGN, area 17 and area 21a of cats (Felis catus).
RESULTS: Induction of training potentiation requires different probability times of training direction: 8~80 in dLGN, 2~8 in area 17, and 1~4 in area 21a. Probability times under the lower limit could not induce significant change of response features, while exceeding the upper limit leads to adaptive depression. Further investigation suggests that for single cell, switch of adaptive depression and training potentiation is stimuli-parameter specific and cell-type related.
CONCLUSIONS: The short-term bi-directional plasticity patterns show progressive differences along dLGN and the visual ventral stream, suggesting inter-level propagation and intra-level uniqueness co-exist during visual information process.

Key words: short-term plasticity, biased adaptation, visual ventral stream, dLGN

冯尚, 崔志畅, 俞洪波. (2019). 视觉系统的“适应-训练双向性”：猫外膝状体、17区、21a区短时程可塑性的层级递进研究. 心理科学进展 , 27(suppl.), 56-56.

Shang FENG, Zhichang CUI, Hongbo YU. (2019). “Adaptation-Training Switch” in Vision System: Hierarchical Progressive Short-term Bi-directional Plasticity in dLGN, Area 17 and Area 21a of Cats. Advances in Psychological Science, 27(suppl.), 56-56.