ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2017, Vol. 25 ›› Issue (12): 2082-2088.doi: 10.3724/SP.J.1042.2017.02082

• 生理心理学专栏 • 上一篇    下一篇

 围产期抑郁引发代际性抑郁障碍及机制

 吴如燕1;  夏宝妹2;  王 薇3,4;  徐桂华5;  陈 刚4   

  1.  (1扬州大学医学院医学心理学教研室, 江苏省中西医结合重点实验室, 江苏 扬州 225001) (2南京特殊教育师范学院康复科学学院医学康复教研室, 南京 210038) (3南京中医药大学心理学院) (4南京中医药大学转化系统生物学与神经科学研究中心, 中医脑病重点实验室) (5南京中医药大学护理学院, 南京 210023)
  • 收稿日期:2017-03-29 出版日期:2017-12-15 发布日期:2017-10-26
  • 通讯作者: 陈刚, E-mail: hdn_2001@yahoo.com; 徐桂华, E-mail: xgh_88@126.com
  • 基金资助:
     国家自然科学基金(81673625); 江苏自然科学基金(BK20151568); 江苏省双创项目(2013455), 江苏六大人才高峰项目(2013-YY-11); 江苏省优势学科; 国家自然青年基金(81701340); 江苏省省自然科学基金(BK20170517); 江苏省省自然科学基金 (BK20170769)。

 Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

 WU Ruyan1; XIA Baomei2; WANG Wei3,4; XU Guihua5; CHEN Gang4   

  1.  (1 Department of Medical Psychology, Medical School, Yangzhou University; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Jiangsu, Yangzhou 225001, China) (2 Nanjing Normal University of Special Education, Faculty of Rehabilitation Science, Department of Rehabilitation, Nanjing 210038, China) (3 School of Psychology, Nanjing University of Chinese Medicine, Nanjing 210023, China) (4 Nanjing University of Chinese Medicine, Center for Translational Systems Biology and Neuroscience, Key laboratory of TCM Brain Research, Nanjing 210023, China) (5 School of Nursying, Nanjing University of Chinese Medicine, Nanjing 210023, China)
  • Received:2017-03-29 Online:2017-12-15 Published:2017-10-26
  • Contact: CHEN Gang, E-mail: hdn_2001@yahoo.com; XU Guihua, E-mail: xgh_88@126.com
  • Supported by:
     

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摘要：  围产期抑郁(peripartum depression, PPD)可对母亲及子女产生不良影响, 显著增加其子女罹患情感障碍的风险, 并且这种影响可代际(transgenerational)持续。PPD引发代际性抑郁障碍的发病机制较为复杂, 经典抗抑郁药物难以起到较好的治疗作用, 因此, 深入研究PPD引发情感障碍及代际性影响的分子机制具有重要意义。本文对下丘脑-垂体-肾上腺轴(hypothalamic–pituitary–adrenal axis, HPA)、催产素(oxytocin, OT)及其信号、突触可塑性以及表观遗传学机制在PPD引发代际性抑郁情感障碍的作用进行讨论, 以期为下一步研究提供依据。

关键词: 围产期抑郁, 代际遗传, 影响机制, 表观遗传学

Abstract:  Peripartum depression (PPD) has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis (HPA), oxytocin (OT), synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.

Key words:  Peripartum depression (PPD), transgenerational depression, mechanisms, Epigenetics

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