ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2013, Vol. 21 ›› Issue (6): 982-989.doi: 10.3724/SP.J.1042.2013.00982

• 生理心理学专栏 • 上一篇    下一篇

CRF受体对五羟色胺系统的调节作用及早期环境因素的影响

原三娜;王琼;邵枫;王玮文   

  1. (1中国科学院心理健康重点实验室, 中国科学院心理研究所, 北京 100101) (2中国科学院大学, 北京 100039) (3北京大学心理学系, 北京 100871)
  • 收稿日期:2013-01-12 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 王玮文
  • 基金资助:

    国家自然科学基金项目(91132728), 中国科学院知识创新项目(KSCX2-EW-J-8)和中国科学院心理健康重点实验室、中国科学院心理研究所资助。

The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors

YUAN Sanna;WANG Qiong;SHAO Feng;WANG Weiwen   

  1. (1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100039, China) (3 Department of Psychology, Peking University, Beijing 100871, China)
  • Received:2013-01-12 Online:2013-06-15 Published:2013-06-15
  • Contact: WANG Weiwen

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1055

被引次数

4

摘要： 早期环境因素持续影响脑与行为的发展, 增加个体成年后应激相关精神疾病患病的易感性。应激反应的中枢启动因子促肾上腺皮质激素释放因子(corticotropin-releasing factor, CRF)通过两种受体CRF1和CRF2调节中缝背核(dorsal raphe nucleus, DRN)-五羟色胺(serotonin, 5-HT)系统, 后者已被证实在应激相关情绪疾患发病和治疗过程中发挥重要作用。已知CRF受体以相互影响相互拮抗的方式动态调节DRN-5-HT系统, 提示这两种受体相对作用的调节对于协调复杂环境中DRN-5-HT系统的应激反应过程起着关键性作用。早期环境因素和遗传因素交互作用导致CRF受体的分布和反应性持续改变并造成DRN-5-HT系统反应异常, 可能是导致应激反应和精神疾病易感性个体差异的重要神经基础。

关键词: 促肾上腺皮质激素释放激素, 早期环境因素, 中缝背核, 五羟色胺

Abstract: Early environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders.

Key words: corticotropin-releasing factor (CRF), early environmental factors, dorsal raphe nucleus (DRN), serotonin (5-HT)