Abstract: The fundamental problem with interpersonal interaction is how we can understand others’ mental and emotional states while characterizing our own concurrent thoughts and feelings to navigate the complex social world efficiently. Recent studies have showed that individuals understand others mainly by simulating self-processing processes; however, such self-processing and mental simulations confuse the self with others to some extent. Therefore, the brain needs to be able to differentiate between the representation of self and others flexibly to carry out successful interpersonal interactions. This ability is known as self-other distinction (SOD). In the present study, various cognitive operations at different processing levels that require SOD, such as perception, action, cognition, and emotion, as well as the research paradigm applicable to the corresponding field, were reviewed. The study of SOD may be more conducive to comprehensively understand the interpersonal interaction process. Furthermore, it can be a useful intervention to improve social cognition, affective disorder, and people with autism. In addition to focusing on the paradigm, internal mechanism, and influencing factors, this study puts forward the prospects for further research emphasizing interventions for special populations.

Key words: self-other distinction, perception, action, cognition, emotion