Abstract: To investigate the effect of different blood glucose level on exploring behavior, leaming and memory in STZ induce KM mice, we selected sixty STZ Ance and assigned them to three groups according to their blood glucose levels, then determined their delaying time and exploring time, the step down test was also executed. We found that the high blood glucose level group showed significantly worse explore behavior and lerning ability but better memory retain ability. No difference was found between the good blood glucose level group and the control group. These resultS suggested that the blood glucose levels affected the exploring behavior and learning and memory in STZ induced KM mice.

Key words: blood glucose level, STZ induced KM mice, explore behavior, learning and memory