Abstract: Huperzine A is a new type of alkaloid, it was first extracted fromHuperzia Serrata in China. The pharmacological actions of huperzine Aare similar to those of physostigmine,but its toxicity is weaker than phy-sostigmine. The purpose of this paper is to observe the effects of hupe-rzine A on the response of dark avoidance in rats, and inquire into theeffects of huperzine A on ECoG in rabbits. The results are as follows: Huperzine A could antagonize memory dysfunction which was produ-ced by scopolamine. Mainly showing prolonged latency and decreased err-or response in the group of huperzine A and scopolomine than the groupof scopolamine. Huperzine A could continuously produce lower voltages and fast wavesin the whole cortex and regular theta rhythm in the hippoeampus. Theresults of ECoG indicated that there was an antagonistic action between hu-perzine A and scopolamine, and that the effects of huperzine A are closely-related to the actions on the central cholinergic system.

Key words: NULL