Abstract: Anisodine is a new alkaloid, it was first isolated from Scopolia tangutica(Anisodus tanguticus) by Chinese phytochemists. The chemical structure andpharmacological actions of anisodine are similar to those of scopolamine. Itstoxicity is weaker than scopolamine. But if someone takes an overdose of thismedicine, it will cause auditory and visual hallucination and disorientation.The purpose of this paper is to observe the effects of anisodine on discriminatedlearning and memory in rats and to inquire into the effects of anisodine onspontaneous and evoked electrical activity of the brain and conditioned reflexof ECoG in rabbits. The results are as follows: There were remarkable effects of anisodine on the discriminated learningand memory in rats. It showed that error responses increased and reactiontime was prolonged and the formation rate of defense conditioned reflex waslower in the medicine group than those in the control group. Anisodine can cause high voltages and slow waves of the whole cortexand obvious inhibition of conditioned reflex of ECoG in ?abbits.

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