Please wait a minute...
Advances in Psychological Science    2016, Vol. 24 Issue (Suppl.) : 28-     DOI:
|
Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study
Qian Li; Yue Yan; Huaiqiang Sun; Xubo Yang; Qiyong Gong; Longqian Liu
Department of Ophthalmology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
Download: PDF(0 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

PURPOSE: To explore the topological properties of brain functional networks derived from resting-state functional magnetic resonance imaging in patients with amblyopia.
METHODS: Seventeen amblyopic subjects and twenty control subjects were recruited to undergo a resting-state functional magnetic resonance imaging scan. The whole-brain functional networks were constructed for each subject, and topological properties such as small-worldness, network effciency and nodal centrality were quantitatively analyzed with graph theoretical analysis.
RESULTS: Both the amblyopic and control groups exhibited small-world properties in brain functional networks, which means a balance between local segregation and global integration for visual information processing. However, compared with control subjects, patients with amblyopia showed altered quantitative values of brain functional networks, characterized with decreased clustering coefficient, lower characteristic path length and decreased network effciency. Topological properties are also significantly altered in some brain regions. These alterations support the disrupted topological organization of brain functional networks in patients with amblyopia.
CONCLUSIONS: Amblyopia is partly resulted from the deficits of visual information transmission. Detection and estimation of altered brain functionl networks can help to further understand the pathophysiological mechanism underlying amblyopia.

Issue Date: 31 December 2016
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Qian Li
Yue Yan
Huaiqiang Sun
Xubo Yang
Qiyong Gong
Longqian Liu
Cite this article:   
Qian Li,Yue Yan,Huaiqiang Sun, et al. Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study[J]. Advances in Psychological Science, 2016, 24(Suppl.): 28-.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/ISuppl./28
No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Advances in Psychological Science
Support by Beijing Magtech