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   2011, Vol. 19 Issue (8) : 1115-1125     DOI:
研究方法 |
The History and Development of Experiment Design for Placebo Effect Studies
ZHANG Wen-Cai;YUAN Li-Zhuang;LU Yun-Qing;LUO Jing
(1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)
(2 College of Education, HeBei Normal University, Shijiazhuang 050024, China)
(3 Learning & Cognition Lab, Capital Normal University, Beijing 100048, China)
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Abstract  Placebo treatment initially was a controlled condition in studying certain active therapeutic effect, but now it has been the study object that the investigators who are interested in. And the experimental paradigm also has kept changing accordingly. Randomized and double-blind design concerns about if the active therapy is more effective than placebo treatment; Deceptive design investigates placebo effect itself by directly compared the placebo treatment and natural history condition; Open-hidden paradigm estimates the size of placebo effect by subtracting hidden effect from open effect; Balanced paradigm can observe placebo effect and therapeutic effect simutaneously; Reinforcement paradigm can produce strong placebo effect with conditioned reinforcement and is an optimized paradigm for studying the mechanism of placebo effect; Transferable paradigm built by our team, can observe the transferable effect from pain domain to emotion domain, is a complement to reinforcement paradigm.
Keywords placebo effect      experimental paradigm      placebo expectation     
Corresponding Authors: LUO Jing   
Issue Date: 15 August 2011
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ZHANG Wen-Cai,YUAN Li-Zhuang,LU Yun-Qing, et al. The History and Development of Experiment Design for Placebo Effect Studies[J]. , 2011, 19(8): 1115-1125.
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