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Advances in Psychological Science    2014, Vol. 22 Issue (4) : 677-684     DOI: 10.3724/SP.J.1042.2014.00677
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Urevaling the Underlying Genetic Factor of Antisocial Behavior Using Genome-Wide Association Study Methodology
HU Wenju;ZHENG Hongli
School of sociology, China University of Political Science and Law, Beijing 100088, China
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Abstract  

Although antisocial behavior is a complex condition with environmental and genetic etiologies, the single susceptibility gene such as the Monoamine oxidase A (MAOA) gene, the serotonin transporter promoter gene (5-HTT) and the catechol O-methyltransferase gene, can’t completely interpret the molecular genetics mechanism of the antisocial behavior. The genome-wide association study (GWAS) methodology from molecular genetics views millions of large number of single nucleotide polymorphisms (SNPs) and copy number variation (CNVs) as genetic markers to search the genetic locus related to external phenotype on the level of entire genome by high-throughput genotyping technology and so it can provide important clues for the further understanding of hereditary factors of antisocial behavior.In order to achieve the analysis for the gene-psychology-environment mechanism of complex traits or behavior, future studies should combine the accurate genotyping techniques with mental and environment factors.

Keywords antisocial behavior      molecular genetics mechanism      genome-wide association study     
Corresponding Authors: ZHENG Hongli   
Issue Date: 15 April 2014
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HU Wenju
ZHENG Hongli
Cite this article:   
HU Wenju,ZHENG Hongli. Urevaling the Underlying Genetic Factor of Antisocial Behavior Using Genome-Wide Association Study Methodology[J]. Advances in Psychological Science, 2014, 22(4): 677-684.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2014.00677     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2014/V22/I4/677
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