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Advances in Psychological Science    2013, Vol. 21 Issue (6) : 982-989     DOI: 10.3724/SP.J.1042.2013.00982
Special Section of Physiological Psychology |
The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors
YUAN Sanna;WANG Qiong;SHAO Feng;WANG Weiwen
(1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100039, China) (3 Department of Psychology, Peking University, Beijing 100871, China)
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Abstract  Early environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders.
Keywords corticotropin-releasing factor (CRF)      early environmental factors      dorsal raphe nucleus (DRN)      serotonin (5-HT)     
Corresponding Authors: WANG Weiwen   
Issue Date: 15 June 2013
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YUAN Sanna,WANG Qiong,SHAO Feng, et al. The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors[J]. Advances in Psychological Science, 2013, 21(6): 982-989.
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