ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2009, Vol. 17 ›› Issue (6): 1274-1280.

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早期经历影响个体成年后行为的表观遗传学机制

李婷;朱熊兆   

  1. 中南大学湘雅二医院医学心理研究中心，长沙 410011
  • 收稿日期:2008-11-11 修回日期:1900-01-01 出版日期:2009-11-15 发布日期:2009-11-15
  • 通讯作者: 朱熊兆

The Role of Epigenetic Regulation in How Early Life Experience Influences Adult Behaviors

LI Ting; ZHU Xiong-Zhao   

  1. Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
  • Received:2008-11-11 Revised:1900-01-01 Online:2009-11-15 Published:2009-11-15
  • Contact: ZHU Xiong-Zhao

PDF (PC)

1004

被引次数

6

摘要： 既往研究已证实早期经历与个体成年后的行为密切相关，然而早期经历对个体成年后的行为产生长期影响的分子生物机制并不清楚。近年来越来越多的研究表明表观遗传因素在早期经历调控成年个体行为中发挥了重要功能。表观遗传是研究没有DNA序列变化，但是可遗传和可逆转的基因组功能的调控。本文试图从早期经历参与调控个体成年后行为表现以及基因表达的相关表观遗传学修饰进行综述。

关键词: 早期经历, 表观遗传学, DNA甲基化, HPA轴

Abstract: Behaviors of human and animals in adulthood is influenced greatly by the experience of its early life in childhood, however, it is still unclear of the molecular mechanisms. Recent researches showed that epigenetic alternation of individuals in its early life contribute to the behavior change of grownup. Epigenetics involves in the heritable but reversible regulation of various gene expression through DNA methylation and chromatin modification without sequence alternation. This article briefly introduced the epigenetic mechanisms which contibuted to gene regulation and behavior change of adult individuals caused by early life experience.

Key words: early life experience, maternal behavior, epigenetics