尼莫地平对高钙和东莨菪碱所致记忆障碍的改善作用

心理学报 ›› 2004, Vol. 36 ›› Issue (02): 208-211.

尼莫地平对高钙和东莨菪碱所致记忆障碍的改善作用

章子贵,杜红燕,吴馥梅

（浙江师范大学生物系，金华　321004）（南京大学生命科学学院，南京　210093）

收稿日期:2003-08-25 修回日期:2003-08-25 出版日期:2004-03-30 发布日期:2004-03-30
通讯作者: 章子贵

THE AMELIORATION OF NIMODIPINE ON CHEMICAL LEARNING AND MEMORY DYSFUNCTION RESULTS FROM INTRAHIPPOCAMPAL INJECTION OF CaCI2 AND SCOPOLAMINE

Zhang Zigui, Du Hongyan, Wu Fumei

（College Of Life and Enviroment Science, Zhe jiang Normal University, Jinhua 321004, China） (College Of Life Science, Nanjing University, Nanjing 210093, China）

Received:2003-08-25 Revised:2003-08-25 Published:2004-03-30 Online:2004-03-30
Contact: Zhang Zigui

摘要/Abstract

摘要： 利用氯化钙和东莨菪碱（海马内注射）分别造成小鼠学习、记忆障碍模型，观察了尼莫地平（腹腔注射）对学习记忆障碍的影响，并以3H—Leu为标记物进行同位素示踪，观察了三种药物对小鼠海马突触体摄取3H—Leu的影响。结果表明，尼莫地平能改善氯化钙和东莨菪碱所致的学习记忆障碍，但不能逆转这两种药物导致的3H—Leu掺入量的减少。提示钙拮抗剂尼莫地平改善化学性记忆障碍的作用不通过促进突触蛋白合成的途径。

关键词: 尼莫地平, 氯化钙, 东莨菪碱, 记忆障碍, 改善作用

Abstract: The influence of nimodipine(ip) on chemical learning and memory dysfunction from intrahippocampal injection of CaCI2 and scopolamine were investigated,and the effects of three agents（CaCI2 , scopolamine and nimodipine ）on the incorporation of 3H—Leu into hippocampal symaptosomes were observed.The results showed that intrahippocampal injection of CaCI2 and scopolamine could cause chemical learning and memory dysfunction significantly (p<0.01 and p<0.05), nimodipine could ameliorate chemical learning and memory dysfunction obviously (p<0.05 and p<0.01), CaCI2 and scopolamine could reduce incorporation of 3H—Leu into hippocampal symaptosomes apparently (p<0.01and p<0.001), but,in vitro,it couldn’t antagonize the reduction of incorporation of 3H—Leu into hippocampal symaptosomes resulted from these two agents .These results suggested that there might exist other mechanism of Ca2+ channel antagonist nimodipine on ameliorating memory impairment instead of improving synaptosomal protein syntheses.

Key words: nimodipine, CaCI2, scopolamine, memory dysfunction, amelioration

中图分类号:

R965

章子贵,杜红燕,吴馥梅. (2004). 尼莫地平对高钙和东莨菪碱所致记忆障碍的改善作用. 心理学报, 36(02), 208-211.

Zhang Zigui, Du Hongyan, Wu Fumei. (2004). THE AMELIORATION OF NIMODIPINE ON CHEMICAL LEARNING AND MEMORY DYSFUNCTION RESULTS FROM INTRAHIPPOCAMPAL INJECTION OF CaCI2 AND SCOPOLAMINE. , 36(02), 208-211.

[1]	于萍, 渠春环,石密,李新旺,郭春彦. 东莨菪碱对大鼠空间参考记忆和工作记忆的不同影响[J]. 心理学报, 2009, 41(04): 337-345.
[2]	李新旺,徐爱红,于斌,王佳,郭春彦. 东莨菪碱对吗啡诱导的大鼠行为敏感化的影响[J]. 心理学报, 2007, 39(2): 299-305.
[3]	章子贵,徐晓虹. 尼莫地平改善高钙所致记忆障碍的脑内突触机制[J]. 心理学报, 2006, 38(03): 436-441.
[4]	章子贵,徐晓虹,吴馥梅. 东莨菪碱所致记忆障碍的脑内突触机制[J]. 心理学报, 1998, 30(3): 332-336.
[5]	翁旭初,陈双双,匡培梓. 中枢胆碱能系统在小鸡记忆形成过程中的作用[J]. 心理学报, 1996, 28(1): 82-88.