ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1985, Vol. 17 ›› Issue (1): 94-97.

• • 上一篇    下一篇

侧脑室注射东莨菪碱对条件反射及对海马神经元自发放电的影响

梅镇彤;黄彦猷;王敬   

  1. 中国科学院上海生理研究所 ,中国科学院上海生理研究所 ,中国科学院上海生理研究所
  • 发布日期:1985-03-25 出版日期:1985-03-25
  • 通讯作者: 梅镇彤

EFFECT OF INTRAVENTRICULAR INJECTION OF SCOPOLAMINE ON ALIMENTARY CONDITIONING AND ON SPONTANEOUS UNIT ACTIVITY OF HIPPOCAMPUS IN RABBITS

Mei Zhentong, Huang Yanyou and Wang Jing (Shanghai Institute of Physiology, Academia Sinica)   

  • Online:1985-03-25 Published:1985-03-25

摘要： 本工作采用食物性运动,条件反射方法和慢性微电极记录技术。条件反射实验在9只兔上进行,海马自发放电的实验在22只兔上进行。在9次实验中,30μg的东莨菪碱注入一侧脑室后,条件反射均受到抑制,而吃食则不受影响。注射剂量为45μg时,注射后3—5分,条件反射完全消失,而吃食行为在了次实验中不受影响,在2次实验中稍有减弱,注射后20分钟左右条件反射开始恢复;侧脑室注射40μg的东莨菪碱后,海马神经元的自发活动无明显改变。文中并对抗胆碱药作用于海马抑制条件反射的可能方式进行了讨论。

关键词: NULL

Abstract: The effect of scopolamine on alimentary conditioning was investigated in 9 rabbits. Intraventricular injection Of scopolamine (30 or 45μg) caused a temporary depression of conditioned reflex, while the animals' food intake was not affected. The spontaneous unit activity of hippocampus was recorded in 22 awake ned restrained rabbits. After intraventricular injection of scopolamine (40μg) which inhibits the conditioning performance, the discharge rate of spontaneous unit activity showed no obvious changes; while after intraventricular injection of cholinergic agonist carbachol (6—8μg), the spontaneous unit activity showed some increase.

Key words: NULL