ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1999, Vol. 31 ›› Issue (2): 236-240.

• • 上一篇    

高压氧对老年小鼠记忆力及脑内Ca~(2+)的影响

郭丹;徐晓虹;张维宁;严玉兰;解洋;盛春宁   

  1. 南京海军医学高等专科学校生理教研室!南京,210099,浙江师范大学生物系!金华,321004,南京大学生命科学与技术系!南京,210093,南京海军医学高等专科学校生理教研室!南京,210099,南京海军医学高等专科学校生理教研室!南京,210099,南京海军医学高等专科学校生理教研室!南京,210099
  • 发布日期:1999-06-25 出版日期:1999-06-25
  • 通讯作者: 郭丹

THE EFFECT OF HYPERBARIC OXYGENATION MEMORY ABILITY AND ON BRAIN SYNAPTOSOME Ca~(2+) IN AGED-MICE

Guo Dan (Dept , of Physiology, Naval Medical College, Nanjing 210099)Xu Xiaohong (Dept, of Biological Science of Zhejiang Normal Universith, Jinhua, 321004)Zhang Weining (Dept .of Biological Science and Techology Nanjing University , Nanjing 210093)   

  • Online:1999-06-25 Published:1999-06-25

摘要： 观察常压（101.3kPa）及高压（253.3kPa）吸氧处理后老年小鼠学习记忆的改善情况，并测定4个主要脑区（皮层、海马、小脑、间脑）突触体内钙离子浓度，结果表明，常压及高压吸氧可明显增强老年小鼠在新异环境中的自发活动能力，并且显著提高记忆保持力，对衰老引起的脑内高钙现象具有明显的抑制效应，其中253.3kPa高压氧降钙效果更明显。脑内高钙与记忆衰退密切相关，提示高压氧可能是通过降钙作用而改善脑老化引起的学习记忆障碍的。

关键词: 高压氧, 开场行为, 一次被动回避反应, 钙离子

Abstract: The spontaneous behavior and the learning memory retention of aged-mice were assessed using open field and one-trial passive avoidance task after atmospheric (101.3kPa)oxygen or hyperbaric (253.3kPa)oxygen treatment (HBOT),At the same time, the synaptosomal free calcium concentration in some main brain regions (cerebral probe [Ca2+],indicat or Fura-2/AM and an AR-CM-MIC cation measurement system The results showed that the spontaneous behavior and explorative response in the openfield significantly increased and the memory retention was remarkably elevated. The high synaptosomal free Ca2+ concentration caused by decrepit was decreased afteratmospheric oxygen or HBOT, and there was a better inhibiting action of HBOT on high level of calcium in the brain, Memory declination was closely related with hypercalcemic phenomenon in the brain. It indicated that the senile memory impediment can be treated by HBOT through decreasing the synaptosomal free Ca2+ concentration.

Key words: hyperbaric oxygenation, open field, one-trial passive avoidance, calcium ion