ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1981, Vol. 13 ›› Issue (1): 102-108. cstr: 32110.14.1981.00102

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锂盐对大鼠脑单胺类和氨基酸类神经介质含量的影响

沈政;肖健;林庶芝;王立华   

  1. 北京大学心理学系 ,北京大学心理学系 ,北京大学心理学系 ,北京大学心理学系
  • 发布日期:1981-03-25 出版日期:1981-03-25

THE EFFECTS OF LITHIUM SALT ON TRANSMITTERS OF MONOAMINES AND AMINOACIDS IN RAT BRAIN

Shen Zheng;Siao Jian;Lin Shu-zhi;Wang Li-hua(Department of Psychology, Beijing University)   

  • Online:1981-03-25 Published:1981-03-25

摘要： 本文以111只大鼠为材料,研究了锂盐重度中毒、血清锂达2.67±0.9meq/升,小脑锂达2.05±0.92meq/kg时,脑及各脑区六种单胺类和氨基酸,类物质含量的改变。结果表明,与正常动物相比,脑多巴胺(DA)和谷氨酸(GA)含量显著下降,5-羟色胺(5-HT),5-羟吲哚醋酸,(5-HIAA)和γ-氨基丁酸(GABA)显著增高,去甲基肾上腺素(NE)虽有下降却未达显著水平。就各脑区而言,端脑DA和GA含量显著下降,5-HIAA和GABA显著升高;间脑的NE显著下降,5-HT和GABA显著升高;脑干中除GABA增高外,其他五种测定物未发生显著改变。 这一结果似乎支持了情感活动和情感性精神病的单胺假说;但它并不是锂盐作用的唯一的和特异性机制,它也引起包括脑干在内的各脑区的GABA含量的增高。

关键词: NULL

Abstract: The changes in brain transmitter contents of monoamines and aminoacids were studied with materials of 111 rats poisoned seriously by lithiumchloride. The result showed that when serum lithum level reached 2.67±0.9meq/L., and cerebellum lithium level reached 2.05±0.92meq/kg., DA and GAwere decreased while 5-HT, 5-HIAA and GABA were increased in thewhole brain (decerebellum) of the experimental group. So far as each areaof brain was concerned, DA was decreased, and 5-HIAA was increasedin Telencephalon; NE was decreased and 5-HT was in creased in Dience-phalon; 4 kinds of monoamines did not display obvious changes in the brainstem but GABA was increased in the whole of the three areas of the brain. The results seem to be supportive to the theory of monoamine aboutaffective disorders. It is possible that effect of lithium on brain is to regulatethe dynamic balance between indoleamines and catacholamines, not only tochange a certain single transmitter. This is not the unique and specificmechanism of lithum effect, because it also makes GABA increase in thewhole of the three areas of the brain, including brain stem.

Key words: NULL