ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2013, Vol. 21 ›› Issue (6): 965-974.doi: 10.3724/SP.J.1042.2013.00965

• 生理心理学专栏 • 上一篇    下一篇

惊反射在创伤后应激障碍研究中的应用：高唤醒与恐惧抑制

董昕文;王超逸;王昌利;李勇辉   

  1. (1中国科学院心理健康重点实验室, 中国科学院心理研究所, 北京 100101) (2中国科学院大学, 北京 100049) (3北京天鸣宏远科技发展有限公司, 北京 100096)
  • 收稿日期:2012-10-08 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 李勇辉
  • 基金资助:

    国家自然基金面上项目(31070911)、中国科学院知识工程创新项目(KSCX2-EW-Q-18)和中国科学院优秀博士论文启动基金支持。

The Progress of Startle Paradigm in the Clinical Studies of PTSD: Hyperarousal and Fear Inhibition

DONG Xinwen;WANG Chaoyi;WANG Changli;LI Yonghui   

  1. (1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Science, Beijing 100101, China) (2 University of Chinese Academy of Science, Beijing 100049, China) (3 Beijing Macroambition Science and Techological Development Co., Ltd, Beijing 100096, China)
  • Received:2012-10-08 Online:2013-06-15 Published:2013-06-15
  • Contact: LI Yonghui

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摘要： 创伤后应激障碍(PTSD)是唯一在诊断标准中包含惊反射改变的精神疾病。相比自我报告法, 对惊反射的实验室测量与总体症状关联更紧密, 并已积累了较多神经机制研究成果, 可作为连接前临床与临床研究的桥梁。在惊反射应用于PTSD研究的初期, 它主要作为PTSD患者高唤醒症状的客观指标, 但是尚未发现惊反射强度的变化与总体症状的明确关系。近年来, 惊反射与情境性焦虑、恐惧抑制等新范式结合, 发现特定情境下惊反射改变是PTSD患者特有的表现。惊反射在创伤应激障碍研究中所取得的新进展对PTSD病理机制的探索和临床诊断都有所启发和推进。

关键词: 惊反射, 创伤后应激障碍, 情境性焦虑, 恐惧抑制

Abstract: Posttraumatic stress disorder (PTSD) is the only mental illness including startle response alteration in its diagnostic criteria. Compared to self-report, startle response measured in laboratory paradigm is associated more closely with overall symptom severity. There has been many research results on the neural mechanism of startle response in both humans and animals, making it possible to connect pre-clinical and clinical studies. At the beginning of using laboratory measurement of starlte response in PTSD clinical research, it has been mainly used as a specific indicator of hyperarousal symptoms, although it has not been firmly established the relation between startle alteration and overall symptoms yet. Recently, some new paradigms based on the theories of contextual anxiety or fear inhibition reveal the specific relationship of startle reflex and severity of PTSD symptom in particular contexts. The new progress in the application of startle response in PTSD will inspire and advance the discovery of pathological mechanism of PTSD and improvement of clinical diagnosis.

Key words: startle, posttraumatic stress disorder, contextual anxiety, fear inhibition