Maternal peripartum depression induced transgenerational  depressive disorder and mechanisms

doi:10.3724/SP.J.1042.2017.02082

Advances in Psychological Science ›› 2017, Vol. 25 ›› Issue (12): 2082-2088.doi: 10.3724/SP.J.1042.2017.02082

• Special Section of Physiological Psychology • Previous Articles Next Articles

Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

WU Ruyan¹; XIA Baomei²; WANG Wei^3,4; XU Guihua⁵; CHEN Gang⁴

(¹ Department of Medical Psychology, Medical School, Yangzhou University; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Jiangsu, Yangzhou 225001, China) (² Nanjing Normal University of Special Education, Faculty of Rehabilitation Science, Department of Rehabilitation, Nanjing 210038, China) (³ School of Psychology, Nanjing University of Chinese Medicine, Nanjing 210023, China) (⁴ Nanjing University of Chinese Medicine, Center for Translational Systems Biology and Neuroscience, Key laboratory of TCM Brain Research, Nanjing 210023, China) (⁵ School of Nursying, Nanjing University of Chinese Medicine, Nanjing 210023, China)

Received:2017-03-29 Online:2017-12-15 Published:2017-10-26
Contact: CHEN Gang, E-mail: hdn_2001@yahoo.com; XU Guihua, E-mail: xgh_88@126.com
Supported by:

Abstract

Abstract: Peripartum depression (PPD) has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis (HPA), oxytocin (OT), synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.

Key words: Peripartum depression (PPD), transgenerational depression, mechanisms, Epigenetics

CLC Number:

B845

WU Ruyan, XIA Baomei, WANG Wei, XU Guihua, CHEN Gang. Maternal peripartum depression induced transgenerational depressive disorder and mechanisms[J]. Advances in Psychological Science, 2017, 25(12): 2082-2088.

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Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

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