ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2017, Vol. 25 ›› Issue (12): 2082-2088.doi: 10.3724/SP.J.1042.2017.02082

• Special Section of Physiological Psychology • Previous Articles     Next Articles

 Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

 WU Ruyan1; XIA Baomei2; WANG Wei3,4; XU Guihua5; CHEN Gang4   

  1.  (1 Department of Medical Psychology, Medical School, Yangzhou University; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Jiangsu, Yangzhou 225001, China) (2 Nanjing Normal University of Special Education, Faculty of Rehabilitation Science, Department of Rehabilitation, Nanjing 210038, China) (3 School of Psychology, Nanjing University of Chinese Medicine, Nanjing 210023, China) (4 Nanjing University of Chinese Medicine, Center for Translational Systems Biology and Neuroscience, Key laboratory of TCM Brain Research, Nanjing 210023, China) (5 School of Nursying, Nanjing University of Chinese Medicine, Nanjing 210023, China)
  • Received:2017-03-29 Online:2017-12-15 Published:2017-10-26
  • Contact: CHEN Gang, E-mail:; XU Guihua, E-mail:
  • Supported by:

Abstract:  Peripartum depression (PPD) has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis (HPA), oxytocin (OT), synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.

Key words:  Peripartum depression (PPD), transgenerational depression, mechanisms, Epigenetics

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