ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2017, Vol. 25 ›› Issue (12): 2043-2056.doi: 10.3724/SP.J.1042.2017.02043

• Special Section of Physiological Psychology • Previous Articles     Next Articles

 Endocannabinoid and post-traumatic stress disorder: Possible mechanisms and clinical application

 ZHU Ye; CAO Chengqi; WANG Li   

  1.  (CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2017-04-08 Online:2017-12-15 Published:2017-10-26
  • Contact: WANG Li, E-mail:
  • Supported by:

Abstract:  Recently, endocannabinoid system has been proposed as a new pharmacological target of post-traumatic stress disorder (PTSD). Empirical studies indicated that endocannabinoid system is closely linked to the occurrence and development of PTSD due to its important roles in regulating the fear memory, anxiety, depression, reward as well as motivation. Several clinical studies also found that appropriate dose of cannabinoids can relieve PTSD symptoms, especially the sleep problems. Future studies should further explore the pathological mechanism of endocannabinoid system in PTSD, increase the clinical security of medicinal cannabinoids,and develop the new kinds of cannabinoid receptor modulators. In addition, investigating of the influence of genetic factors and heterogeneity of responses in the effect of endocannabinoid on treatment of PTSD will also promote the early identification of the patients and the development of precision medicine.

Key words: endocannabinoid, post-traumatic stress disorder, fear memory, anxiety, depression

CLC Number: