ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2013, Vol. 21 ›› Issue (6): 982-989.doi: 10.3724/SP.J.1042.2013.00982

• Special Section of Physiological Psychology • Previous Articles     Next Articles

The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors

YUAN Sanna;WANG Qiong;SHAO Feng;WANG Weiwen   

  1. (1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100039, China) (3 Department of Psychology, Peking University, Beijing 100871, China)
  • Received:2013-01-12 Online:2013-06-15 Published:2013-06-15
  • Contact: WANG Weiwen

Abstract: Early environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders.

Key words: corticotropin-releasing factor (CRF), early environmental factors, dorsal raphe nucleus (DRN), serotonin (5-HT)