Abstract:

Loss of control in substance seeking and use of addicts is closely related to response inhibition. Many studies have explored this relationship in context of substance-related cues. Substance cues can be automatically captured by attention and also induce non-automatic approach-motivated state. As a consequence, these cues may consume limited cognitive resources through a stimulus-driven and a state-dependent manner in order to influence addicts' response inhibition. And these effects also play important roles in the development and maintenance of addictive behaviors. Further research should be carried out to reveal the neural mechanisms of both manners, clarify how motivations and attitudes towards substance use modulate these effects, conduct research in real situations, and discover more effective interventions.

Key words: substance addiction, substance-related cues, response inhibition, stimulus-driven effects, state-dependent effects