Abstract: As multiple utilization of the brain imaging and genetic analysis, it has greatly advanced the discoveries on neurobiology of emotional regulation in recent ten years. The growing converging evidences showed neural circuits of emotion regulation primarily involved in the connection and interaction of dorsal-ventral prefrontal circuits, prefrontal-amygdala circuits and cortical-limbic circuits, which might be affected by variant of genes such as 5-hydroxytryptamine transporter (5-HTT), Catechol-O- methyltransferase (COMT), tryptophan hydroxylase 2 (TPH2), and the interaction of different genes aslo had important effect on the neural circuits of emotion regulation.

Key words: emotional regulation, affective disorder, neural circuits, genetic polymorphisms, imaging genetics