ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2017, Vol. 25 ›› Issue (12): 2013-2020.doi: 10.3724/SP.J.1042.2017.02013

• Special Section of Physiological Psychology • Previous Articles     Next Articles

 Endoplasmic reticulum stress and posttraumatic stress disorder

 HAN Fang; LIU Hong; XIAO Bing; LIU Dongjuan; WEN Lili; ZHAO Wei; KONG Fanzhen; ZHAO Dongmei; LI Xiaoyan; SHI Yuxiu   

  1.  (Department of Histology and Embryology, Lab of PTSD, Basic Medical College, China Medical University, Shenyang 110122, China)
  • Received:2017-04-28 Online:2017-12-15 Published:2017-10-25
  • Contact: HAN Fang, E-mail: fhan@cmu.edu.cn
  • Supported by:
     

Abstract:  Endoplasmic reticulum stress (ERS) induce the protein folding reaction, and then make endoplasmic reticulum three pathway PERK, IRE1 and ATF6 separate from the endoplasmic reticulum chaperone, activate of three pathways and start the apoptosis pathway. We used the animal model of posttraumatic stress disorder: single prolonged stress (SPS) to find endoplasmic reticulum stress cause the endoplasmic reticulum chaperone and protect neurons at the early stage of SPS, but in the later period of SPS, when the ability decreased that endoplasmic reticulum chaperone correct for the folding protein, ERS could accelerate the activation of three path and induce the cell apoptosis.

Key words: Endoplasmic reticulum stress, single prolonged stress, PERK, IRE1, ATF6

CLC Number: