Abstract: The nigrostriatal was damaged on one side of the brain with aneurotoxin, 6-OHDA. The function of the two cerebral hemispheres inanimals produced asymmetry. With lesions in the rats, cocaine inducedthe rotational behavior. Forty-three adult female albino rats of the Holtzman strain wereobserved. The results showed a 85--100% dopamine depletion in 38 ofthese rats (88.37%), their lesions were ideal. However, three rats(6.98%) had a less than 60% dopamine depletion, and two rats (4.65%)only a 60--80% dopamine depletion. How to Prepare and automatically record the rotational behaviorin rats with rotometre, and measure dopamine level in striatal by highperformance liquid chromatography with electrochemical detection wasdealt with in detail in this paper.

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